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(11)

EP 3 233 112 A2

(12)

(88) Date of publication A3: 11.08.2016 (43) Date of publication: 25.10.2017 Bulletin 2017/43 (21) Application number: 15808213.1 (22) Date of filing: 11.12.2015

(51) International Patent Classification (IPC):  A61K 39/00(2006.01) C07K 16/24(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/EP2015/079384 (87) International publication number: WO 2016/096640 (23.06.2016 Gazette 2016/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 17.12.2014 GB 201422502 (71) Applicant: Cancer Research Technology Limited London EC1V 4AD (GB)

(72) Inventors: BALKWILL, Frances Rosemary London EC1Y 2AN (GB) MCCAFFERTY, John Babraham Cambridge CB22 3AT (GB) GRAHAM, Gerard John Giffnock Glasgow G46 7AA (GB) VELLATT, Aneesh Karatt Comberton Cambridge CB23 7DN (GB) SLAVNY, Peter London EC1V 4AD (GB) (74) Representative: Kiddle, Simon John et al Mewburn Ellis LLP City Tower 40 Basinghall Street London EC2V 5DE City Tower 40 Basinghall Street London EC2V 5DE (GB)