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EP 3 234 106 A1

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(43) Date of publication: 25.10.2017 Bulletin 2017/43 (21) Application number: 15871241.4 (22) Date of filing: 18.12.2015

(51) International Patent Classification (IPC):  C12N 1/21(2006.01) C07K 14/025(2006.01) C07K 14/47(2006.01) A61K 39/02(2006.01) A61K 39/39(2006.01) C12N 15/31(2006.01) C07K 14/195(2006.01) C07K 16/28(2006.01) A61K 39/12(2006.01) A61K 39/395(2006.01) (86) International application number: PCT/US2015/066896 (87) International publication number: WO 2016/100929 (23.06.2016 Gazette 2016/25)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 19.12.2014 US 201462094472 P 19.12.2014 US 201462094349 P 14.04.2015 US 201562147463 P 03.12.2015 US 201562262896 P (71) Applicants: Advaxis, Inc. Princeton, NJ 08540 (US) Augusta University Research Institute, Inc. Augusta, GA 30912 (US)

(72) Inventors: KHLEIF, Samir Silver Springs, Maryland 20906 (US) MKRTICHYAN, Mikayel Millbrae, CA 94030 (US) PETIT, Robert Newtown, PA 18940 (US) WALLECHA, Anu Yardley, PA 19067 (US) (74) Representative: J A Kemp  14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)