(19)
(11) EP 3 242 888 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
02.06.2021 Bulletin 2021/22

(45) Mention of the grant of the patent:
25.11.2020 Bulletin 2020/48

(21) Application number: 16716673.5

(22) Date of filing: 07.01.2016
(51) International Patent Classification (IPC): 
C07K 14/71(2006.01)
A61P 19/08(2006.01)
A61K 38/17(2006.01)
(86) International application number:
PCT/IB2016/000403
(87) International publication number:
WO 2016/110786 (14.07.2016 Gazette 2016/28)

(54)

SOLUBLE FGFR3 DECOYS FOR TREATING SKELETAL GROWTH DISORDERS

LÖSLICHE FGFR3-KÖDER ZUR BEHANDLUNG VON WACHSTUMSSTÖRUNGEN

LEURRES FGFR3 SOLUBLES POUR LE TRAITEMENT DE TROUBLES DE LA CROISSANCE OSSEUSE


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 07.01.2015 EP 15290003

(43) Date of publication of application:
15.11.2017 Bulletin 2017/46

(60) Divisional application:
20202446.9 / 3828198

(73) Proprietors:
  • Pfizer Inc.
    New York, NY 10017 (US)
  • INSERM - Institut National de la Santé et de la Recherche Médicale
    75013 Paris (FR)
  • Université Côte d'Azur
    06100 Nice Cedex 2 (FR)

(72) Inventors:
  • GOUZE, Elvire
    06410 Biot (FR)
  • GARCIA, Stéphanie
    06200 Nice (FR)

(74) Representative: Zwicker, Jörk 
ZSP Patentanwälte PartG mbB Hansastraße 32
80686 München
80686 München (DE)


(56) References cited: : 
WO-A1-2014/111467
WO-A2-2008/133873
US-A1- 2003 235 589
WO-A2-2007/014123
WO-A2-2011/084711
   
  • S. GARCIA ET AL: "Postnatal Soluble FGFR3 Therapy Rescues Achondroplasia Symptoms and Restores Bone Growth in Mice", SCIENCE TRANSLATIONAL MEDICINE, vol. 5, no. 203, 18 September 2013 (2013-09-18), XP055194295, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.3006247 cited in the application
  • F. H. CHEN ET AL: "Interaction of Cartilage Oligomeric Matrix Protein/Thrombospondin 5 with Aggrecan", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 34, 22 June 2007 (2007-06-22), pages 24591-24598, XP055194302, ISSN: 0021-9258, DOI: 10.1074/jbc.M611390200
  • D LI ET AL: "A novel decoy receptor fusion protein for FGF-2 potently inhibits tumour growth", BRITISH JOURNAL OF CANCER, vol. 111, no. 1, 29 May 2014 (2014-05-29), pages 68-77, XP055160715, ISSN: 0007-0920, DOI: 10.1038/bjc.2014.282
  • SU-JEONG HWANG ET AL: "High-level Expression and Purification of a Designed Angiopoietin-1 Chimeric Protein, COMP-Ang1, Produced in Chinese Hamster Ovary Cells", JOURNAL OF PROTEIN CHEMISTRY, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 27, no. 5, 9 May 2008 (2008-05-09), pages 319-326, XP019609300, ISSN: 1573-4943
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).