(19)
(11) EP 3 250 701 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
24.02.2021 Bulletin 2021/08

(45) Mention of the grant of the patent:
04.11.2020 Bulletin 2020/45

(21) Application number: 16701783.9

(22) Date of filing: 27.01.2016
(51) International Patent Classification (IPC): 
C12P 13/06(2006.01)
C12N 15/00(2006.01)
(86) International application number:
PCT/EP2016/051728
(87) International publication number:
WO 2016/120345 (04.08.2016 Gazette 2016/31)

(54)

GENETICALLY MODIFIED MICROORGANISMS HAVING IMPROVED TOLERANCE TOWARDS L-SERINE

VERFAHREN ZUR HERSTELLUNG VON L-SERIN MITTELS GENETISCH MODIFIZIERTER MIKROORGANISMEN MIT MANGEL AN SERINABBAUPFADEN

PROCÉDÉ POUR LA PRODUCTION DE L-SÉRINE UTILISANT DES MICRO-ORGANISMES GÉNÉTIQUEMENT MODIFIÉS PRÉSENTANT UNE DÉFICIENCE EN VOIES DE DÉGRADATION DE SÉRINE


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 27.01.2015 EP 15152643

(43) Date of publication of application:
06.12.2017 Bulletin 2017/49

(60) Divisional application:
20204768.4

(73) Proprietor: CysBio ApS
2970 Hørsholm (DK)

(72) Inventors:
  • MUNDHADA, Hemanshu
    2800 Kgs. Lyngby (DK)
  • NIELSEN, Alex Toftgaard
    2960 Rungsted Kyst (DK)

(74) Representative: Zacco Denmark A/S 
Arne Jacobsens Allé 15
2300 Copenhagen S
2300 Copenhagen S (DK)


(56) References cited: : 
WO-A1-2007/144018
CN-A- 102 703 371
   
  • P. PETERS-WENDISCH ET AL: "Metabolic Engineering of Corynebacterium glutamicum for L-Serine Production", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 71, no. 11, 1 November 2005 (2005-11-01), pages 7139-7144, XP055017302, ISSN: 0099-2240, DOI: 10.1128/AEM.71.11.7139-7144.2005
  • YU LI ET AL: "Construction of Escherichia coli strains producing-serine from glucose", BIOTECHNOLOGY LETTERS, SPRINGER NETHERLANDS, DORDRECHT, vol. 34, no. 8, 1 May 2012 (2012-05-01), pages 1525-1530, XP035089780, ISSN: 1573-6776, DOI: 10.1007/S10529-012-0937-0 cited in the application
  • SHUJUAN LAI ET AL: "Metabolic engineering and flux analysis of Corynebacterium glutamicum for L-serine production", SCIENCE CHINA LIFE SCIENCES, SP SCIENCE CHINA PRESS, HEIDELBERG, vol. 55, no. 4, 9 May 2012 (2012-05-09), pages 283-290, XP035052326, ISSN: 1869-1889, DOI: 10.1007/S11427-012-4304-0
  • XIAO ZHANG ET AL: "Deficiency in l-serine deaminase results in abnormal growth and cell division of Escherichia coli K-12", MOLECULAR MICROBIOLOGY, 1 July 2008 (2008-07-01), pages ???-???, XP055199519, ISSN: 0950-382X, DOI: 10.1111/j.1365-2958.2008.06315.x cited in the application
   
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