| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
13.02.2015 EP 15305217
|
| (43) |
Date of publication of application: |
|
20.12.2017 Bulletin 2017/51 |
| (73) |
Proprietors: |
|
- INSERM - Institut National de la Santé et de la
Recherche Médicale
75013 Paris (FR)
- Centre National de la Recherche Scientifique
(C.N.R.S.)
75016 Paris (FR)
- Université de Paris
75006 Paris (FR)
- Commissariat à l'Energie Atomique et aux Energies
Alternatives
75015 Paris (FR)
- CNAM Conservatoire National des Arts des Metiers
75003 Paris (FR)
|
|
| (72) |
Inventors: |
|
- BRIDIER-NAHMIAS, Antoine
75010 Paris (FR)
- WERNER, Michel
91191 Gif-sur-Yvette (FR)
- LESAGE, Pascale
75010 Paris (FR)
|
| (74) |
Representative: Inserm Transfert |
|
7, rue Watt
75013 Paris
75013 Paris (FR) |
| (56) |
References cited: :
|
| |
|
|
- DEVINE, J. BOEKE: "Invading the yeast nucleus: a nuclear localization signal at the
c terminus of ty1 integrase is required for transposition in vivo", MOL CELL BIOL,
vol. 18, no. 2, February 1998 (1998-02), pages 1115-1124, XP002743549, cited in the
application
- WILHELM MARCELLE ET AL: "Expression of an active form of recombinant Ty1 reverse transcriptase
in Escherichia coli: A fusion protein containing the C-terminal region of the Ty1
integrase linked to the reverse transcriptase-RNase H domain exhibits polymerase and
RNase H activities", BIOCHEMICAL JOURNAL, vol. 348, no. 2, 1 June 2000 (2000-06-01),
pages 337-342, XP002743550, ISSN: 0264-6021
- S. P. MOORE; L. A. RINCKEL; D. J. GARFINKEL: "A Ty1 integrase nuclear localization
signal required for retrotransposition", MOLECULAR AND CELLULAR BIOLOGY, vol. 18,
no. 2, February 1998 (1998-02), pages 1105-1114, XP002743551, cited in the application
- MOORE SHARON P ET AL: "Expression and partial purification of enzymatically active
recombinant Ty1 integrase in Saccharomyces cerevisiae", PROCEEDINGS OF THE NATIONAL
ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 91, no. 5, 1994, pages 1843-1847,
XP002743552, ISSN: 0027-8424
- MOORE SHARON P ET AL: "Substrate specificity of Ty1 integrase", JOURNAL OF VIROLOGY,
vol. 69, no. 8, 1995, pages 4683-4692, XP002743553, ISSN: 0022-538X
- WILHELM M ET AL: "Role of integrase in reverse transcription of the Saccharomyces
cerevisiae retrotransposon Ty1", EUKARYOTIC CELL, vol. 4, no. 6, June 2005 (2005-06),
pages 1057-1065, XP002743554,
- OLIVIER DELELIS ET AL: "Integrase and integration: biochemical activities of HIV-1
integrase", RETROVIROLOGY, vol. 5, 17 December 2008 (2008-12-17), pages 1-13, DOI:
doi: 10.1186/1742-4690-5-114
- ROBERT CRAIGIE: "The molecular biology of HIV integrase", FUTURE VIROL., vol. 7, no.
7, July 2012 (2012-07), pages 679-686, DOI: 10.2217/FVL.12.56
|
|
