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<ep-patent-document id="EP16739870B8W1" file="EP16739870W1B8.xml" lang="en" country="EP" doc-number="3261678" kind="B8" correction-code="W1" date-publ="20210317" status="c" dtd-version="ep-patent-document-v1-5">
<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>BDM Ver 1.7.2 (20 November 2019) -  2999001/0</B007EP></eptags></B000><B100><B110>3261678</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20210317</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>16739870.0</B210><B220><date>20160122</date></B220><B240><B241><date>20170710</date></B241><B242><date>20190723</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>201562107210 P</B310><B320><date>20150123</date></B320><B330><ctry>US</ctry></B330></B300><B400><B405><date>20210317</date><bnum>202111</bnum></B405><B430><date>20180103</date><bnum>201801</bnum></B430><B450><date>20201111</date><bnum>202046</bnum></B450><B452EP><date>20201006</date></B452EP><B480><date>20210317</date><bnum>202111</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>A61K  47/50        20170101AFI20200305BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>A61P  35/00        20060101ALI20200305BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>C07K  16/30        20060101ALI20200305BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>C07K  19/00        20060101ALI20200305BHEP        </text></classification-ipcr><classification-ipcr sequence="5"><text>C12N   9/80        20060101ALI20200305BHEP        </text></classification-ipcr><classification-ipcr sequence="6"><text>C12N   9/96        20060101ALI20200305BHEP        </text></classification-ipcr><classification-ipcr sequence="7"><text>A61K  39/395       20060101ALI20200305BHEP        </text></classification-ipcr><classification-ipcr sequence="8"><text>C07K  16/28        20060101ALI20200305BHEP        </text></classification-ipcr><classification-ipcr sequence="9"><text>A61K  47/68        20170101ALI20200305BHEP        </text></classification-ipcr><classification-ipcr sequence="10"><text>A61K  47/64        20170101ALI20200305BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>ANTIKÖRPER-UREASE-KONJUGATE FÜR THERAPEUTISCHE ZWECKE</B542><B541>en</B541><B542>ANTIBODY-UREASE CONJUGATES FOR THERAPEUTIC PURPOSES</B542><B541>fr</B541><B542>CONJUGUÉS ANTICORPS-URÉASE POUR DES FINS THÉRAPEUTIQUES</B542></B540><B560><B561><text>EP-A1- 0 824 019</text></B561><B561><text>WO-A1-97/15316</text></B561><B561><text>WO-A1-2004/009112</text></B561><B561><text>WO-A1-2013/185215</text></B561><B561><text>WO-A1-2014/165985</text></B561><B561><text>CA-A1- 2 130 072</text></B561><B561><text>CA-A1- 2 492 472</text></B561><B561><text>CA-A1- 2 877 505</text></B561><B561><text>CA-A1- 2 908 475</text></B561><B561><text>US-A- 4 762 707</text></B561><B562><text>Heman Chao ET AL: "Development of an alkalizing antibody-enzyme conjugate for NSCLC treatment that is in Phase I clinical testing Preclinical Studies Abstract Background Starting Dose Derivations Acknowledgement", L-DOS47 PRESENTATION AT AACR 2013 ANNUAL MEETING, 5 April 2013 (2013-04-05), XP055285609, Retrieved from the Internet: URL:http://www.helixbiopharma.com/wp-conte nt/uploads/2014/02/Helix-BioPharma-AACR.pd f [retrieved on 2016-07-04]</text></B562><B562><text>HELIX BIOPHARMA: "L-DOS47: Single domain antibody conjugated anticancer therapy", BIT'S 5TH ANNUAL INTERNATION CONGRESS OF ANTIBODIES, , 1 January 2013 (2013-01-01), pages 1-35, XP009505019, Retrieved from the Internet: URL:http://www.helixbiopharma.com/wp-conte nt/uploads/2014/02/LDOS47-ICA-2013-HZ-.pdf</text></B562><B562><text>CHAO H: "DOS47 - Killing cancer by altering the tumor microenvironment", DRUG DELIVERY TECHNOLOGY, DRUG DELIVERY TECHNOLOGY, LLC, US, vol. 11, no. 1, 1 January 2011 (2011-01-01), pages 68-72, XP002763192, ISSN: 1537-2898</text></B562><B562><text>CHANDLER H M ET AL: "An investigation of the use of urease-antibody conjugates in enzyme immunoassays", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 53, no. 2, 17 September 1982 (1982-09-17), pages 187-194, XP023900599, ISSN: 0022-1759, DOI: 10.1016/0022-1759(82)90140-5 [retrieved on 1982-09-17]</text></B562><B562><text>Sigma: "ANTI-MOUSE IgG (WHOLE MOLECULE) UREASE CONJUGATE", , 6 January 2006 (2006-01-06), pages 1-1, XP055517511, Retrieved from the Internet: URL:https://www.sigmaaldrich.com/content/d am/sigma-aldrich/docs/Sigma/Datasheet/8/u1 004dat.pdf [retrieved on 2018-10-22]</text></B562><B562><text>MEYERHOFF M E ET AL: "Electrode-based enzyme immunoassays using urease conjugates", ANALYTICAL BIOCHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 95, no. 2, 1 June 1979 (1979-06-01), pages 483-493, XP024827776, ISSN: 0003-2697, DOI: 10.1016/0003-2697(79)90760-7 [retrieved on 1979-06-01]</text></B562><B562><text>AN-PING DENG ET AL: "Application of a polyaniline based ammonium sensor for the amperometric immunoassay of a urease conjugated Tal 1 protein", ANALYTICA CHIMICA ACTA, vol. 461, no. 1, 1 June 2002 (2002-06-01), pages 49-55, XP055517531, AMSTERDAM, NL ISSN: 0003-2670, DOI: 10.1016/S0003-2670(02)00251-9</text></B562><B562><text>TIAN ET AL.: 'Production and characterization of a camelid single domain antibody-urease enzyme conjugate for the treatment of cancer' BIOCONJUGATE CHEMISTRY vol. 26, no. 6, 17 June 2015, pages 1144 - 1155, XP055271801 DOI: 10.1021/ACS.BIOCONJCHEM.5B00237</text></B562><B562><text>CHAO ET AL.: 'Development of an alkalizing antibody-enzyme conjugate for NSCLC treatment that is in Phase I clinical testing' L-DOS47 PRESENTATION AT AACR 2013 ANNUAL MEETING, [Online] 05 April 2013, pages 1 - 1, XP055285609 Retrieved from the Internet: &lt;URL:HTTP://WWW.HELIXBIOPHARMA.COM/WP-CONTE NT/UPLOADS/2014/02/HELIX-BIOPHARMA-AACR.PDF &gt;</text></B562><B562><text>HELIX BIOPHARMA: 'L-DOS47: Single domain antibody conjugated anticancer therapy' BIT'S 5TH ANNUAL INTERNATION CONGRESS OF ANTIBODIES, [Online] 2013, XP009505019 Retrieved from the Internet: &lt;URL:WWW.HELIXBIOPHARMA.COM/WP-CONTENT/UPLO ADS/2014/02/LDOS47-ICA-2013-HZ.PDF&gt;</text></B562><B562><text>CHAO: 'DOS47 - Killing cancer by altering the tumor microenvironment' DRUG DEVELOPMENT AND DELIVERY vol. 11, no. 1, 01 January 2011, pages 68 - 72, XP002763192</text></B562><B562><text>WONG ET AL.: 'Urease-induced alkalinization of extracellular pH and its antitumor activity in human breast and lung cancers' JOURNAL OF EXPERIMENTAL THERAPEUTICS AND ONCOLOGY vol. 5, no. 2, 01 January 2005, pages 93 - 99, XP009147420</text></B562><B565EP><date>20181102</date></B565EP></B560></B500><B700><B720><B721><snm>CHAO, Heman</snm><adr><str>5 Hogaboom Avenue</str><city>Aurora, Ontario L4G 0E5</city><ctry>CA</ctry></adr></B721><B721><snm>WONG, Wah Yau</snm><adr><str>8812-188 St. NW</str><city>Edmonton, Alberta T5T 5Z8</city><ctry>CA</ctry></adr></B721><B721><snm>TIAN, Baomin</snm><adr><str>4325 McMullen Way SW</str><city>Edmonton, Alberta T6W 1N5</city><ctry>CA</ctry></adr></B721><B721><snm>GASPAR, Kimberly Jayne</snm><adr><str>11-416 23rd St. East</str><city>Saskatoon, Saskatchewan S7K 0J7</city><ctry>CA</ctry></adr></B721><B721><snm>KUMAR, Praveen</snm><adr><str>115 Fawcett Crescent</str><city>Saskatoon, Saskatchewan S7T 0G1</city><ctry>CA</ctry></adr></B721></B720><B730><B731><snm>Helix Biopharma Corp.</snm><iid>101735936</iid><irf>AXH/84455EP1</irf><adr><str>9120 Leslie Street 
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