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EP 3 262 035 A1

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(43) Date of publication: 03.01.2018 Bulletin 2018/01 (21) Application number: 16705959.1 (22) Date of filing: 24.02.2016

(51) International Patent Classification (IPC):  C07D 403/10(2006.01) C07D 413/10(2006.01) C07D 417/14(2006.01) C07D 491/04(2006.01) C07D 403/14(2006.01) C07D 417/10(2006.01) C07D 487/04(2006.01) (86) International application number: PCT/EP2016/053805 (87) International publication number: WO 2016/135163 (01.09.2016 Gazette 2016/35)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 25.02.2015 WO PCT/CN2015/073258 (71) Applicant: F. Hoffmann-La Roche AG 4070 Basel (CH)

(72) Inventors: BLAQUIERE, Nicole South San Francisco, California 94080 (US) CASTANEDO, Georgette South San Francisco, California 94080 (US) FENG, Jianwen A. South San Francisco, California 94080 (US) CRAWFORD, James John South San Francisco, California 94080 (US) LEE, Wendy South San Francisco, California 94080 (US) LIN, Xingyu Beijing 100176 (CN) HU, Baihua Beijing 100176 (CN) WU, Guosheng Beijing 100176 (CN) (74) Representative: Schirlin, Julien  F. Hoffmann-La Roche AG CLP - Patent Department Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)