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(11)

EP 3 262 216 A2

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(88) Date of publication A3: 27.10.2016 (43) Date of publication: 03.01.2018 Bulletin 2018/01 (21) Application number: 16756185.1 (22) Date of filing: 23.02.2016

(51) International Patent Classification (IPC):  C40B 40/08(2006.01) C07K 16/00(2006.01) C07K 16/22(2006.01) C40B 50/06(2006.01) C12N 15/73(2006.01) C07K 16/10(2006.01) C12N 15/10(2006.01) (86) International application number: PCT/US2016/019128 (87) International publication number: WO 2016/137992 (01.09.2016 Gazette 2016/35)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 24.02.2015 US 201562120352 P (71) Applicant: Academia Sinica Nankang, Taipei 115 (TW)

(72) Inventors: CHEN, Hong-Sen Taipei 115 (R.O.C) (TW) CHEN, Ing-Chien Taipei 115 (R.O.C) (TW) TUNG, Chao-Ping Taipei 115 (R.O.C) (TW) HOU, Shin-Chen Taichung City 402 (R.O.C.) (TW) YU, Chung-Ming Taipei 115 (R.O.C.) (TW) YANG, Chi-Kai Taipei 115 (R.O.C.) (TW) CHIU, Yi-Kai Taipei 115 (R.O.C.) (TW) YANG, An-suei Emeryville, CA 94608 (US) (74) Representative: Lang, Christian  LangPatent Anwaltskanzlei IP Law Firm Rosenheimer Straße 139 81671 München 81671 München (DE)