| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
27.02.2015 JP 2015039071
|
| (43) |
Date of publication of application: |
|
03.01.2018 Bulletin 2018/01 |
| (60) |
Divisional application: |
|
20162312.1 |
| (73) |
Proprietor: Kyushu University,
National University Corporation |
|
Fukuoka-shi
Fukuoka 812-8581 (JP) |
|
| (72) |
Inventors: |
|
- FUKUI, Yoshinori
Fukuoka-shi
Fukuoka 812-8581 (JP)
- URUNO, Takehito
Fukuoka-shi
Fukuoka 812-8581 (JP)
- KANAI, Motomu
Tokyo 113-8654 (JP)
- MATSUNAGA, Shigeki
Tokyo 113-8654 (JP)
- SHIRAI, Takahiro
Tokyo 113-8654 (JP)
- YOKOYAMA, Shigeyuki
Yokohama-shi
Kanagawa 230-0045 (JP)
- HONMA, Teruki
Yokohama-shi
Kanagawa 230-0045 (JP)
- NIINO, Mutsuko
Yokohama-shi
Kanagawa 230-0045 (JP)
- TAKAYA, Daisuke
Yokohama-shi
Kanagawa 230-0045 (JP)
|
| (74) |
Representative: Vossius & Partner
Patentanwälte Rechtsanwälte mbB |
|
Siebertstrasse 3 81675 München 81675 München (DE) |
| (56) |
References cited: :
WO-A1-2006/024823 WO-A2-2008/079787 JP-A- 2011 522 056
|
WO-A1-2012/157389 CA-A1- 2 726 588
|
|
| |
|
|
- CARDAMA ET AL.: "Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using
a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines", ANTI-CANCER
AGENTS IN MEDICINAL CHEMISTRY, vol. 14, 1875-599, 1 January 2014 (2014-01-01), pages
840-855, XP55551163,
- AKIHIKO NISHIKIMI ET AL: "Blockade of Inflammatory Responses by a Small-Molecule Inhibitor
of the Rac Activator DOCK2", CHEMISTRY AND BIOLOGY., vol. 19, no. 4, 1 April 2012
(2012-04-01), pages 488-497, XP055551155, GB ISSN: 1074-5521, DOI: 10.1016/j.chembiol.2012.03.008
- BOUQUIER N ET AL: "A Cell Active Chemical GEF Inhibitor Selectively Targets the Trio/RhoG/Rac1
Signaling Pathway", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 16, no.
6, 26 June 2009 (2009-06-26), pages 657-666, XP026211470, ISSN: 1074-5521, DOI: 10.1016/J.CHEMBIOL.2009.04.012
[retrieved on 2009-06-25]
- FENG, H. ET AL.: 'Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine
residue Y722 by Src family kinases mediates EGFRvIII- driven glioblastoma tumorigenesis'
PNAS vol. 109, no. 8, 2012, pages 3018 - 3023, XP055478393
- JARZYNKA, M. J. ET AL.: 'ELMO1 and Dock180, a Bipartite Rac1 Guanine Nucleotide Exchange
Factor, Promote Human Glioma Cell Invasion' CANCER RES. vol. 67, no. 15, 2007, pages
7203 - 7211, XP055478404
- LAURIN, M. ET AL.: 'Rac-specific guanine nucleotide exchange factor DOCK1 is a critical
regulator of HER2-mediated breast cancer metastasis' PNAS vol. 110, no. 18, 2013,
pages 7434 - 7439, XP055478420
- SANEMATSU, F. ET AL.: 'Phosphatidic Acid- dependent Recruitment and Function of the
Rac Activator DOCK1 during Dorsal Ruffle Formation' JBC vol. 288, no. 12, 2013, pages
8092 - 8100, XP055478423
- OWA, T. ET AL.: 'Synthesis and Biological Evaluation of N-(7-Indolyl)-3- pyridinesulfonamide
Derivatives as Potent Antitumor Agents' BIOORGANIC & MEDICINAL CHEMISTRY LETTERS vol.
12, 2002, pages 2097 - 2100, XP002980660
|
|