(19)
(11) EP 3 263 133 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
15.07.2020 Bulletin 2020/29

(45) Mention of the grant of the patent:
01.04.2020 Bulletin 2020/14

(21) Application number: 16755729.7

(22) Date of filing: 26.02.2016
(51) International Patent Classification (IPC): 
A61K 45/00(2006.01)
A61K 31/4439(2006.01)
A61K 31/4453(2006.01)
A61K 31/541(2006.01)
A61P 35/00(2006.01)
G01N 33/15(2006.01)
A61K 31/4412(2006.01)
A61K 31/444(2006.01)
A61K 31/5377(2006.01)
A61K 31/55(2006.01)
A61P 35/04(2006.01)
G01N 33/50(2006.01)
(86) International application number:
PCT/JP2016/055927
(87) International publication number:
WO 2016/136985 (01.09.2016 Gazette 2016/35)

(54)

PYRIDINONE COMPOUND AND USE THEREOF

PYRIDINONVERBINDUNG UND VERWENDUNG DAVON

COMPOSÉ PYRIDINONE ET UTILISATION DE CE DERNIER


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 27.02.2015 JP 2015039071

(43) Date of publication of application:
03.01.2018 Bulletin 2018/01

(60) Divisional application:
20162312.1

(73) Proprietor: Kyushu University, National University Corporation
Fukuoka-shi Fukuoka 812-8581 (JP)

(72) Inventors:
  • FUKUI, Yoshinori
    Fukuoka-shi Fukuoka 812-8581 (JP)
  • URUNO, Takehito
    Fukuoka-shi Fukuoka 812-8581 (JP)
  • KANAI, Motomu
    Tokyo 113-8654 (JP)
  • MATSUNAGA, Shigeki
    Tokyo 113-8654 (JP)
  • SHIRAI, Takahiro
    Tokyo 113-8654 (JP)
  • YOKOYAMA, Shigeyuki
    Yokohama-shi Kanagawa 230-0045 (JP)
  • HONMA, Teruki
    Yokohama-shi Kanagawa 230-0045 (JP)
  • NIINO, Mutsuko
    Yokohama-shi Kanagawa 230-0045 (JP)
  • TAKAYA, Daisuke
    Yokohama-shi Kanagawa 230-0045 (JP)

(74) Representative: Vossius & Partner Patentanwälte Rechtsanwälte mbB 
Siebertstrasse 3
81675 München
81675 München (DE)


(56) References cited: : 
WO-A1-2006/024823
WO-A2-2008/079787
JP-A- 2011 522 056
WO-A1-2012/157389
CA-A1- 2 726 588
   
  • CARDAMA ET AL.: "Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines", ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol. 14, 1875-599, 1 January 2014 (2014-01-01), pages 840-855, XP55551163,
  • AKIHIKO NISHIKIMI ET AL: "Blockade of Inflammatory Responses by a Small-Molecule Inhibitor of the Rac Activator DOCK2", CHEMISTRY AND BIOLOGY., vol. 19, no. 4, 1 April 2012 (2012-04-01), pages 488-497, XP055551155, GB ISSN: 1074-5521, DOI: 10.1016/j.chembiol.2012.03.008
  • BOUQUIER N ET AL: "A Cell Active Chemical GEF Inhibitor Selectively Targets the Trio/RhoG/Rac1 Signaling Pathway", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 16, no. 6, 26 June 2009 (2009-06-26), pages 657-666, XP026211470, ISSN: 1074-5521, DOI: 10.1016/J.CHEMBIOL.2009.04.012 [retrieved on 2009-06-25]
  • FENG, H. ET AL.: 'Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII- driven glioblastoma tumorigenesis' PNAS vol. 109, no. 8, 2012, pages 3018 - 3023, XP055478393
  • JARZYNKA, M. J. ET AL.: 'ELMO1 and Dock180, a Bipartite Rac1 Guanine Nucleotide Exchange Factor, Promote Human Glioma Cell Invasion' CANCER RES. vol. 67, no. 15, 2007, pages 7203 - 7211, XP055478404
  • LAURIN, M. ET AL.: 'Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis' PNAS vol. 110, no. 18, 2013, pages 7434 - 7439, XP055478420
  • SANEMATSU, F. ET AL.: 'Phosphatidic Acid- dependent Recruitment and Function of the Rac Activator DOCK1 during Dorsal Ruffle Formation' JBC vol. 288, no. 12, 2013, pages 8092 - 8100, XP055478423
  • OWA, T. ET AL.: 'Synthesis and Biological Evaluation of N-(7-Indolyl)-3- pyridinesulfonamide Derivatives as Potent Antitumor Agents' BIOORGANIC & MEDICINAL CHEMISTRY LETTERS vol. 12, 2002, pages 2097 - 2100, XP002980660
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).