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EP 3 268 075 A1

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(43) Date of publication: 17.01.2018 Bulletin 2018/03 (21) Application number: 16762701.7 (22) Date of filing: 14.03.2016

(51) International Patent Classification (IPC):  A61M 25/00(2006.01) A61N 7/02(2006.01) A61N 7/00(2006.01) (86) International application number: PCT/US2016/022320 (87) International publication number: WO 2016/145439 (15.09.2016 Gazette 2016/37)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 12.03.2015 US 201562132459 P (71) Applicant: Cibiem, Inc. Los Altos, CA 94022 (US)

(72) Inventors: SINELNIKOV, Yegor D. Los Altos, CA 94022 (US) ENGELMAN, Zoar Jacob Los Altos, CA 94022 (US) GELFAND, Mark Los Altos, CA 94022 (US) GRASSE, Martin M. Los Altos, CA 94022 (US) KOSS, Timothy A. Los Altos, CA 94022 (US) MARKHAM, Michael Brick Los Altos, CA 94022 (US) MARTIN, Kenneth M. Los Altos, CA 94022 (US) SUORSA, Veijo T. Los Altos, CA 94022 (US) TAIMISTO, Miriam H. Los Altos, CA 94022 (US) WEI, Xian Los Altos, CA 94022 (US) (74) Representative: Peterreins Schley  Patent- und Rechtsanwälte Hermann-Sack-Strasse 3 80331 München 80331 München (DE)