(19)
(11) EP 3 268 464 A1

(12)

(43) Date of publication:
17.01.2018 Bulletin 2018/03

(21) Application number: 16769297.9

(22) Date of filing: 04.03.2016
(51) International Patent Classification (IPC): 
C12N 5/078(2010.01)
A61K 35/12(2015.01)
A61K 38/19(2006.01)
 C12N 5/0784(2010.01)
A61K 35/17(2015.01)
A61K 38/20(2006.01)
(86) International application number:
PCT/US2016/020987
(87) International publication number:
WO 2016/153761 (29.09.2016 Gazette 2016/39)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
MA MD

(30) Priority: 13.03.2015 US 201514658095
13.03.2015 US 201561953726 P
30.12.2015 US 201514985303

(71) Applicant: Czerniecki, Brian, J.
Haddonfield, NJ 08033 (US)

(72) Inventors:
  • KOSKI, Gary, K.
    Akron, OH 44333 (US)
  • DATTA, Jashodeep
    Philadelphia, PA 19129 (US)
  • CZERNIECKI, Brian, J.
    Tampa, FL 33602-5738 (US)

(74) Representative: Biggi, Cristina 
Bugnion S.p.A. Viale Lancetti 17
20158 Milano
20158 Milano (IT)

   


(54) METHODS FOR MONITORING CD4+ T-HELPER TYPE 1 RESPONSE IN CANCER AND IMMUNE RESTORATION