| (84) |
Designated Contracting States: |
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AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
16.03.2015 EP 15159296
06.11.2015 EP 15193513
|
| (43) |
Date of publication of application: |
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24.01.2018 Bulletin 2018/04 |
| (73) |
Proprietor: OGEDA N.V. |
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1800 Vilvoorde (BE) |
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| (72) |
Inventors: |
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- HOVEYDA, Hamid
1190 Bruxelles (BE)
- FRASER, Graeme
1470 Bousval (BE)
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| (74) |
Representative: Icosa |
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83 avenue Denfert-Rochereau
75014 Paris
75014 Paris (FR) |
| (56) |
References cited: :
WO-A1-2009/130240
WO-A1-2013/050424
WO-A1-2014/154896
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WO-A1-2011/121137
WO-A1-2014/154895
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- KARAGIANNIDES ET AL: "Substance P as a Novel Anti-obesity Target", GASTROENTEROLOGY,
ELSEVIER, PHILADELPHIA, PA, vol. 134, no. 3, 3 March 2008 (2008-03-03) , pages 747-755.e1,
XP022516869, ISSN: 0016-5085, DOI: 10.1053/J.GASTRO.2007.12.032
- R. RAMALHO ET AL: "Substance P antagonist improves both obesity and asthma in a mouse
model", ALLERGY, vol. 68, no. 1, 26 November 2012 (2012-11-26), pages 48-54, XP055189568,
ISSN: 0105-4538, DOI: 10.1111/all.12052
- IORDANES KARAGIANNIDES ET AL: "Substance P (SP)-Neurokinin-1 Receptor (NK-1R) Alters
Adipose Tissue Responses to High-Fat Diet and Insulin Action", ENDOCRINOLOGY, vol.
152, no. 6, 1 June 2011 (2011-06-01), pages 2197-2205, XP055189537, ISSN: 0013-7227,
DOI: 10.1210/en.2010-1345
- S. Y. LI ET AL: "Neurokinin B Receptor Antagonism Decreases Luteinising Hormone Pulse
Frequency and Amplitude and Delays Puberty Onset in the Female Rat", JOURNAL OF NEUROENDOCRINOLOGY,
vol. 26, no. 8, 22 July 2014 (2014-07-22), pages 521-527, XP055189545, ISSN: 0953-8194,
DOI: 10.1111/jne.12167
- JUDITH A SIUCIAK ET AL: "Disruption of the neurokinin-3 receptor (NK3) in mice leads
to cognitive deficits", PSYCHOPHARMACOLOGY, SPRINGER, BERLIN, DE, vol. 194, no. 2,
10 June 2007 (2007-06-10) , pages 185-195, XP019537364, ISSN: 1432-2072, DOI: 10.1007/S00213-007-0828-6
- HAMID R. HOVEYDA ET AL: "Discovery and Optimization of Novel Antagonists to the Human
Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part I)", JOURNAL
OF MEDICINAL CHEMISTRY, vol. 58, no. 7, 4 March 2015 (2015-03-04), pages 3060-3082,
XP055187482, ISSN: 0022-2623, DOI: 10.1021/jm5017413
- HAMID R. HOVEYDA ET AL: "Optimization of Novel Antagonists to the Neurokinin-3 Receptor
for the Treatment of Sex-Hormone Disorders (Part II)", ACS MEDICINAL CHEMISTRY LETTERS,
vol. 6, no. 7, 9 July 2015 (2015-07-09), pages 736-740, XP055270385, United States
ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.5b00117
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