ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................*JBDM Ver 2.0.24 - 2999001/03271015CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120231101W173deBibliographieenBibliographyfrBibliographieEP16710199.7201603162017101620190528enenen1515929620150316EP1519351320151106EP2023110120234420180124201804202309272023392023032020231101202344A61P 3/04 20060101AFI20160927BHEP A61K 31/472 20060101ALI20160927BHEP A61K 31/4725 20060101ALI20160927BHEP A61K 31/495 20060101ALI20160927BHEP A61K 31/4985 20060101ALI20160927BHEP A61K 31/472 20130101 LI20160504BHEP A61K 31/4725 20130101 LI20160504BHEP A61K 31/495 20130101 LI20160504BHEP A61K 31/4985 20130101 FI20181011BHEP A61P 3/04 20180101 LI20181011BHEP deNK-3-REZEPTORANTAGONISTEN ZUR THERAPEUTISCHEN ODER KOSMETISCHEN BEHANDLUNG VON ÜBERMÄSSIGEM KÖRPERFETTenNK-3 RECEPTOR ANTAGONISTS FOR THERAPEUTIC OR COSMETIC TREATMENT OF EXCESS BODY FATfrANTAGONISTES DES RÉCEPTEURS NK-3 POUR LE TRAITEMENT THERAPEUTIQUE OU COSMÉTIQUE DE L'EXCÈS DE GRAISSE CORPORELLEWO-A1-2009/130240WO-A1-2011/121137WO-A1-2013/050424WO-A1-2014/154895WO-A1-2014/154896KARAGIANNIDES ET AL: "Substance P as a Novel Anti-obesity Target", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA, vol. 134, no. 3, 3 March 2008 (2008-03-03) , pages 747-755.e1, XP022516869, ISSN: 0016-5085, DOI: 10.1053/J.GASTRO.2007.12.032R. RAMALHO ET AL: "Substance P antagonist improves both obesity and asthma in a mouse model", ALLERGY, vol. 68, no. 1, 26 November 2012 (2012-11-26), pages 48-54, XP055189568, ISSN: 0105-4538, DOI: 10.1111/all.12052IORDANES KARAGIANNIDES ET AL: "Substance P (SP)-Neurokinin-1 Receptor (NK-1R) Alters Adipose Tissue Responses to High-Fat Diet and Insulin Action", ENDOCRINOLOGY, vol. 152, no. 6, 1 June 2011 (2011-06-01), pages 2197-2205, XP055189537, ISSN: 0013-7227, DOI: 10.1210/en.2010-1345S. Y. LI ET AL: "Neurokinin B Receptor Antagonism Decreases Luteinising Hormone Pulse Frequency and Amplitude and Delays Puberty Onset in the Female Rat", JOURNAL OF NEUROENDOCRINOLOGY, vol. 26, no. 8, 22 July 2014 (2014-07-22), pages 521-527, XP055189545, ISSN: 0953-8194, DOI: 10.1111/jne.12167JUDITH A SIUCIAK ET AL: "Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits", PSYCHOPHARMACOLOGY, SPRINGER, BERLIN, DE, vol. 194, no. 2, 10 June 2007 (2007-06-10) , pages 185-195, XP019537364, ISSN: 1432-2072, DOI: 10.1007/S00213-007-0828-6HAMID R. HOVEYDA ET AL: "Discovery and Optimization of Novel Antagonists to the Human Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part I)", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 7, 4 March 2015 (2015-03-04), pages 3060-3082, XP055187482, ISSN: 0022-2623, DOI: 10.1021/jm5017413HAMID R. HOVEYDA ET AL: "Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II)", ACS MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 7, 9 July 2015 (2015-07-09), pages 736-740, XP055270385, United States ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.5b00117HOVEYDA, HamidRue Meyerbeer, 721190 BruxellesBEFRASER, GraemeRue Bois des Conins 19A1470 BousvalBEOGEDA N.V.102012531ICHEM-475/EP/3Medialaan 501800 VilvoordeBEIcosa10121833783 avenue Denfert-Rochereau75014 ParisFRALATBEBGCHCYCZDEDKEEESFIFRGBGRHRHUIEISITLILTLULVMCMKMTNLNOPLPTRORSSESISKSMTREP201605573520160316enWO201614671220160922201638