| (84) |
Designated Contracting States: |
|
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL
NO PL PT RO RS SE SI SK SM TR |
| (30) |
Priority: |
20.03.2015 US 201562136228 P
03.11.2015 US 201562250378 P
|
| (43) |
Date of publication of application: |
|
24.01.2018 Bulletin 2018/04 |
| (60) |
Divisional application: |
|
20156388.9 |
| (73) |
Proprietor: The United States of America, as represented by
the Secretary, Department of Health and
Human Services |
|
Bethesda, MD 20852-7660 (US) |
|
| (72) |
Inventors: |
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- CONNORS, Mark
Bethesda, MD 20814 (US)
- HUANG, Jinghe
Bethesda, MD 20892 (US)
- KANG, Byong, Ha
Bethesda, MD 20814 (US)
- MASCOLA, John
Bethesda, MD 20892 (US)
- ISHIDA, Elise
Bethesda, MD 20892 (US)
- ZHOU, Tongqing
Bethesda, MD 20892 (US)
- KWONG, Peter
Bethesda, MD 20892 (US)
- ZHENG, Anqi
Bethesda, MD 20892 (US)
|
| (74) |
Representative: Gowshall, Jonathan Vallance |
|
Forresters IP LLP
Skygarden
Erika-Mann-Strasse 11
80636 München
80636 München (DE) |
| (56) |
References cited: :
WO-A1-2012/154312
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WO-A1-2013/163427
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- XUELING WU ET AL: "Rational design of envelope identifies broadly neutralizing human
monoclonal antibodies to HIV-1", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT
OF SCIENCE, US, vol. 329, no. 5993, 13 August 2010 (2010-08-13), pages 856-861, XP002669441,
ISSN: 0036-8075, DOI: 10.1126/SCIENCE.1187659 [retrieved on 2010-07-08]
- MCKAY BROWN ET AL: "Tolerance to single, but not multiple, amino acid replacements
in antibody V-H CDR2: A means of minimizing B cell wastage from somatic hypermutation?",
THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, vol. 156,
no. 9, 1 January 1996 (1996-01-01), pages 3285-3291, XP002649029, ISSN: 0022-1767
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