(19)
(11) EP 3 275 993 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
29.09.2021 Bulletin 2021/39

(45) Mention of the grant of the patent:
25.08.2021 Bulletin 2021/34

(21) Application number: 16772843.5

(22) Date of filing: 29.03.2016
(51) International Patent Classification (IPC): 
C12M 1/34(2006.01)
G01N 33/48(2006.01)
 C12Q 1/02(2006.01)
G01N 33/483(2006.01)
(52) Cooperative Patent Classification (CPC):
G01N 33/48; C12M 1/34; C12Q 1/02; G01N 33/483; G01N 33/4833
(86) International application number:
PCT/JP2016/060146
(87) International publication number:
WO 2016/158962 (06.10.2016 Gazette 2016/40)

(54)

DEVICE FOR PRODUCING INFORMATION FOR CELL ANALYSIS, METHOD FOR PRODUCING INFORMATION FOR CELL ANALYSIS, AND PROGRAM

VORRICHTUNG ZUR ERZEUGUNG VON INFORMATIONEN ZUR ZELLANALYSE, VERFAHREN ZUR ERZEUGUNG VON INFORMATIONEN ZUR ZELLANALYSE UND PROGRAMM

DISPOSITIF DE PRODUCTION D'INFORMATIONS POUR ANALYSE CELLULAIRE, PROCÉDÉ DE PRODUCTION D'INFORMATIONS POUR ANALYSE CELLULAIRE, ET PROGRAMME

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 30.03.2015 JP 2015070319
30.03.2015 JP 2015070320
30.03.2015 JP 2015070410

(43) Date of publication of application:
31.01.2018 Bulletin 2018/05

(73) Proprietor: Inotech Co., Ltd.
Hiroshima-shi Hiroshima 732-0825 (JP)

(72) Inventors:
  • KATO, Ryuji
    Nagoya-shi Aichi 464-8601 (JP)
  • KANIE, Kei
    Nagoya-shi Aichi 464-8601 (JP)
  • SASAKI, Hiroto
    Nagoya-shi Aichi 464-8601 (JP)
  • KAWAI, Shun
    Nagoya-shi Aichi 464-8601 (JP)

(74) Representative: Appleyard Lees IP LLP 
15 Clare Road
Halifax HX1 2HY
Halifax HX1 2HY (GB)


(56) References cited: : 
WO-A1-2010/098105
JP-A- 2012 175 946
 JP-A- 2011 030 494
   
  • KEI SASAKI ET AL: "Image-based focused counting of dividing cells for non-invasive monitoring of regenerative medicine products", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, vol. 120, no. 5, 24 April 2015 (2015-04-24), pages 582-590, XP055431535, NL ISSN: 1389-1723, DOI: 10.1016/j.jbiosc.2015.03.002
  • FUMIKO MATSUOKA ET AL: "Characterization of time-course morphological features for efficient prediction of osteogenic potential in human mesenchymal stem cells : Morphological Features Relevant for Quality Prediction", BIOTECHNOLOGY AND BIOENGINEERING, vol. 111, no. 7, 1 July 2014 (2014-07-01), pages 1430-1439, XP055431564, ISSN: 0006-3592, DOI: 10.1002/bit.25189
  • FUMIKO MATSUOKA ET AL: "Morphology-Based Prediction of Osteogenic Differentiation Potential of Human Mesenchymal Stem Cells", PLOS ONE, vol. 8, no. 2, 21 February 2013 (2013-02-21), page e55082, XP055431610, DOI: 10.1371/journal.pone.0055082
  • MIKA SUGA ET AL: "Development of a Monitoring Method for Nonlabeled Human Pluripotent Stem Cell Growth by Time-Lapse Image Analysis : Image Analysis Method for hPSC Growth", STEM CELLS TRANSLATIONAL MEDICINE : SCTM, vol. 4, no. 7, 13 May 2015 (2015-05-13), pages 720-730, XP055431659, Durham ISSN: 2157-6564, DOI: 10.5966/sctm.2014-0242
  • SASAKI ET AL: "Image-based cell quality assessment: modeling of cell morphology and quality for clinical cell therapy", 1 January 2013 (2013-01-01), COMPUTATIONAL MODELING IN TISSUE ENGINEERING, SPRINGER BERLIN HEIDELBERG, 2012, DE, PAGE(S) 207 - 226, XP009502107, ISBN: 978-3-642-32562-5 * page 209 - page 216; figures 3-5 *
  • SASAKI K ET AL: "Orientation based segmentation for phase-contrast microscopic image of confluent cell", ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE, IEEE, 3 July 2013 (2013-07-03), pages 3323-3326, XP032489778, ISSN: 1557-170X, DOI: 10.1109/EMBC.2013.6610252 [retrieved on 2013-09-25]
  • CARPENTER ANNE E ET AL: "CellProfiler: image analysis software for identifying and quantifying cell phenotypes", GENOME BIOLOGY, BIOMED CENTRAL LTD., LONDON, GB, vol. 7, no. 10, 31 October 2006 (2006-10-31), page R100, XP021027289, ISSN: 1465-6906, DOI: 10.1186/GB-2006-7-10-R100
  • HIROTO SASAKI ET AL: "Label-Free Morphology-Based Prediction of Multiple Differentiation Potentials of Human Mesenchymal Stem Cells for Early Evaluation of Intact Cells", PLOS ONE, vol. 9, no. 4, 1 January 2014 (2014-01-01) , pages e93952-e93952, XP055317757, US ISSN: 1932-6203, DOI: 10.1371/journal.pone.0093952
  • KAZUAKI TOKUNAGA ET AL: "Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells", SCIENTIFIC REPORTS, vol. 4, 11 November 2014 (2014-11-11), page 6996, XP055208875, DOI: 10.1038/srep06996
  • SASAKI HIROTO ET AL: "Comparisons of cell culture medium using distribution of morphological features in microdevice", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, ELSEVIER, AMSTERDAM, NL, vol. 121, no. 1, 3 July 2015 (2015-07-03), pages 117-123, XP029365560, ISSN: 1389-1723, DOI: 10.1016/J.JBIOSC.2015.05.011
  • SASAKI KEI ET AL: "Non-invasive quality evaluation of confluent cells by image-based orientation heterogeneity analysis", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, ELSEVIER, AMSTERDAM, NL, vol. 121, no. 2, 13 July 2015 (2015-07-13) , pages 227-234, XP029378601, ISSN: 1389-1723, DOI: 10.1016/J.JBIOSC.2015.06.012
  • SASAKI, H. ET AL.: 'Label-free morphology-based prediction ofmultiple differentiation potentials of human mesenchymal stemcells for early evaluation of intact cells' PLOS ONE vol. 9, no. 4, 2014, ISSN 1932-6203 page E93952, XP055317757
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).