                         SEQUENCE LISTING

<110>  Ablynx N.V.
 
<120>  Bispecific CXCR4-CD4 Polypeptides with potent anti-HIV activity

<130>  P15-004-PCT-1

<150>  US 62/142127
<151>  2015-04-02

<160>  136   

<170>  PatentIn version 3.5

<210>  1
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210>  2
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Gly Ile Ser Ser Ile Pro Leu Pro Leu Leu Gln Ile Tyr Thr 
1               5                   10                  15      


Ser Asp Asn Tyr Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met 
            20                  25                  30          


Lys Glu Pro Cys Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe 
        35                  40                  45              


Leu Pro Thr Ile Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly Asn 
    50                  55                  60                  


Gly Leu Val Ile Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met 
65                  70                  75                  80  


Thr Asp Lys Tyr Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val 
                85                  90                  95      


Ile Thr Leu Pro Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe 
            100                 105                 110         


Gly Asn Phe Leu Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu 
        115                 120                 125             


Tyr Ser Ser Val Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu 
    130                 135                 140                 


Ala Ile Val His Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala 
145                 150                 155                 160 


Glu Lys Val Val Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Thr 
                165                 170                 175     


Ile Pro Asp Phe Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr 
            180                 185                 190         


Ile Cys Asp Arg Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln 
        195                 200                 205             


Phe Gln His Ile Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu 
    210                 215                 220                 


Ser Cys Tyr Cys Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His 
225                 230                 235                 240 


Gln Lys Arg Lys Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe 
                245                 250                 255     


Phe Ala Cys Trp Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe 
            260                 265                 270         


Ile Leu Leu Glu Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val 
        275                 280                 285             


His Lys Trp Ile Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys 
    290                 295                 300                 


Leu Asn Pro Ile Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser 
305                 310                 315                 320 


Ala Gln His Ala Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile 
                325                 330                 335     


Leu Ser Lys Gly Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser 
            340                 345                 350         


Glu Ser Ser Ser Phe His Ser Ser 
        355                 360 


<210>  3
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  4
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  4

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Ser Gly Val Arg Ser Gly Val Ser Ala Ile Tyr 
    50                  55                  60                  


Gly Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Thr Cys Ala Ala Ser Ala Ile Gly Ser Gly Ala Leu Arg Arg 
            100                 105                 110         


Phe Glu Tyr Asp Tyr Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  5
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Ser Gly Val Arg Ser Gly Val Ser Ala Ile Tyr 
    50                  55                  60                  


Gly Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Thr Cys Ala Ala Ser Ala Ile Gly Ser Gly Ala Leu Arg Arg 
            100                 105                 110         


Phe Glu Tyr Asp Tyr Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  6
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Arg Ser Gly Val Arg Ser Gly Val Ser Ala Ile Tyr 
    50                  55                  60                  


Gly Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Val Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Thr Cys Ala Ala Ser Ala Ile Gly Ser Gly Ala Leu Arg Arg 
            100                 105                 110         


Phe Glu Tyr Asp Tyr Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  7
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Val Arg Thr Gly Val Ser Ala Leu Tyr 
    50                  55                  60                  


Gly Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Lys Met Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Thr Cys Ala Ala Ser Ala Ile Gly Ser Gly Ala Leu Arg Arg 
            100                 105                 110         


Phe Glu Tyr Asp Ser Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  8
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Val Arg Thr Gly Val Ser Ala Leu Tyr 
    50                  55                  60                  


Gly Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Lys Met Lys Pro Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Thr Cys Ala Ala Ser Ala Ile Gly Ser Gly Ala Leu Arg Arg 
            100                 105                 110         


Phe Glu Tyr Asp Ser Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  9
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Gly Pro Ser Lys Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Lys Phe Val Asn Thr Asp Ser Thr Trp Ser Arg Ser Glu Met 
            100                 105                 110         


Tyr Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  10
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  10

Glu Val Gln Leu Val Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Thr Phe Ser Val Ala 
            20                  25                  30          


Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly Gln Gln Arg Ala Leu Val 
        35                  40                  45              


Ala Asp Ile Ser Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Leu Ala Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Arg Thr Ser Gly Trp Arg Thr Arg Ser Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  11
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Thr Phe Ser Val Ala 
            20                  25                  30          


Thr Leu Gly Trp Tyr Arg Gln Ala Pro Gly Gln Gln Arg Ala Leu Val 
        35                  40                  45              


Ala Asp Ile Ser Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Leu Ala Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Arg Thr Ser Gly Trp Arg Thr Arg Ser Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  12
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Val Asn Ile Phe Gly Ser Ile 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asn Leu Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Arg Ile Asn Tyr Ala Asp Ser Arg Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val His Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Arg Ile Gly Gln Arg Thr Leu Thr Phe Thr Pro Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  13
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Leu Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Ser Pro Thr His Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Gly Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Tyr Ser Ser Arg Asp Ala Ala Tyr Arg Ser Asp Tyr Asp 
            100                 105                 110         


Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  14
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Arg Thr Ser Ser Tyr Ala 
            20                  25                  30          


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Gly 
        35                  40                  45              


Thr Ile Ser Arg Thr Asn Ser Arg Thr Lys Tyr Ala Asp Phe Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Ser Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Lys Trp Thr Gly Asn Ser Tyr His Asp Tyr Thr Trp Ser Lys Val 
            100                 105                 110         


Asp Glu Tyr Asn Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  15
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Cys Ala Leu Ser Ser Ala Gly Ser Ala Leu Thr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Val Ala Gly Gly Tyr Cys Thr Arg Ala Gly Val Tyr Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Ser Thr Ser 
            20                  25                  30          


Thr Met Gly Trp Tyr Ser Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Asp Ile Thr Phe Leu Gly Ser Ala Lys Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Lys Ile Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Arg Gln Ser Thr Phe Arg Gly Val His Tyr Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Pro Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Leu Thr Ala Thr His Thr Tyr Glu Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Ala Ser Tyr 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Asp Glu Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Arg Gly Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Asp Arg Trp Trp Arg Pro Ala Gly Leu Gln Trp Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  19
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Arg Ser Ile Leu Asp Phe Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Thr Thr Ile Ala Arg Ala Gly Ala Thr Lys Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Arg Val Phe Asp Leu Pro Asn Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  20
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn Val Met 
            20                  25                  30          


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
        35                  40                  45              


Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp Gly Tyr 
            100                 105                 110         


Asp Phe Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  21
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  21

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn 
            20                  25                  30  


<210>  22
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn 
            20                  25                  30  


<210>  23
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn 
            20                  25                  30  


<210>  24
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Asn 
            20                  25                  30  


<210>  25
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Asn 
            20                  25                  30  


<210>  26
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser 
            20                  25                  30  


<210>  27
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  27

Glu Val Gln Leu Val Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Thr Phe Ser 
            20                  25                  30  


<210>  28
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Thr Phe Ser 
            20                  25                  30  


<210>  29
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Val Asn Ile Phe Gly 
            20                  25                  30  


<210>  30
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser 
            20                  25                  30  


<210>  31
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Arg Thr Ser 
            20                  25                  


<210>  32
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
            20                  25                  


<210>  33
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe 
            20                  25                  


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  34

Asn Tyr Ala Met Gly 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  35

Arg Tyr Ala Met Gly 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  36

Val Ala Thr Leu Gly 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  37

Ser Ile Ala Met Ala 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  38

Ser Tyr Ala Met Ala 
1               5   


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  39

Ser Arg Ala Ala Met Gly 
1               5       


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  40

Ser Thr Ser Thr Met Gly 
1               5       


<210>  41
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 2

<400>  41

Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 2

<400>  42

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
1               5                   10                  


<210>  43
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 2

<400>  43

Trp Tyr Arg Gln Ala Pro Gly Gln Gln Arg Ala Leu Val Ala 
1               5                   10                  


<210>  44
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 2

<400>  44

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asn Leu Val Ala 
1               5                   10                  


<210>  45
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 2

<400>  45

Trp Phe Arg Gln Ala Leu Gly Lys Glu Arg Glu Leu Val Ala 
1               5                   10                  


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 2

<400>  46

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Gly 
1               5                   10                  


<210>  47
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 2

<400>  47

Trp Tyr Ser Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  


<210>  48
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 2

<400>  48

Ala Ile Thr Arg Ser Gly Val Arg Ser Gly Val Ser Ala Ile Tyr Gly 
1               5                   10                  15      


Asp Ser Val Lys Asp 
            20      


<210>  49
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 2

<400>  49

Ala Ile Ser Arg Ser Gly Val Arg Thr Gly Val Ser Ala Leu Tyr Gly 
1               5                   10                  15      


Asp Ser Val Lys Asp 
            20      


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 2

<400>  50

Ala Ile Gly Trp Gly Pro Ser Lys Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 2

<400>  51

Asp Ile Ser Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Arg Gly 
1               5                   10                  15      


<210>  52
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 2

<400>  52

Ser Ile Ser Ser Gly Gly Arg Ile Asn Tyr Ala Asp Ser Arg Lys Gly 
1               5                   10                  15      


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 2

<400>  53

Ala Ile Gly Trp Ser Pro Thr His Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 2

<400>  54

Thr Ile Ser Arg Thr Asn Ser Arg Thr Lys Tyr Ala Asp Phe Val Glu 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 2

<400>  55

Cys Ala Leu Ser Ser Ala Gly Ser Ala Leu Thr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 2

<400>  56

Asp Ile Thr Phe Leu Gly Ser Ala Lys Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  57
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  57

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Thr Cys Ala Ala 
            20                  25                  30          


<210>  58
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  58

Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Thr Cys Ala Ala 
            20                  25                  30          


<210>  59
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  59

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Lys Met Lys Pro Glu Asp Thr Ala Val Tyr Thr Cys Ala Ala 
            20                  25                  30          


<210>  60
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  60

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Ala Ala 
            20                  25                  30          


<210>  61
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  61

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Leu Ala Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
            20                  25                  30          


<210>  62
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  62

Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Val His Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  63
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  63

Arg Phe Thr Met Ser Arg Asp Asn Gly Lys Asn Thr Val Phe Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  64
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  64

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Ser Leu Gln 
1               5                   10                  15      


Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  65
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  65

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Val Ala 
            20                  25                  30          


<210>  66
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  66

Arg Phe Thr Ile Ser Arg Asp Lys Ile Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Tyr Cys Asn Ala 
            20                  25                  30          


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3

<400>  67

Ser Ala Ile Gly Ser Gly Ala Leu Arg Arg Phe Glu Tyr Asp Tyr 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3

<400>  68

Ser Ala Ile Gly Ser Gly Ala Leu Arg Arg Phe Glu Tyr Asp Ser 
1               5                   10                  15  


<210>  69
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3

<400>  69

Lys Phe Val Asn Thr Asp Ser Thr Trp Ser Arg Ser Glu Met Tyr Thr 
1               5                   10                  15      


Tyr 
    


<210>  70
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3

<400>  70

Arg Thr Ser Gly Trp Arg Thr Arg Ser Asn Tyr 
1               5                   10      


<210>  71
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3

<400>  71

Gly Arg Ile Gly Gln Arg Thr Leu Thr Phe Thr Pro Asp Tyr 
1               5                   10                  


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3

<400>  72

Lys Tyr Ser Ser Arg Asp Ala Ala Tyr Arg Ser Asp Tyr Asp Tyr Asn 
1               5                   10                  15      


Tyr 
    


<210>  73
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3

<400>  73

Lys Trp Thr Gly Asn Ser Tyr His Asp Tyr Thr Trp Ser Lys Val Asp 
1               5                   10                  15      


Glu Tyr Asn Val 
            20  


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3

<400>  74

Gly Gly Tyr Cys Thr Arg Ala Gly Val Tyr Pro Tyr 
1               5                   10          


<210>  75
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3

<400>  75

Arg Gln Ser Thr Phe Arg Gly Val His Tyr Asn Tyr 
1               5                   10          


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 4

<400>  76

Ser Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  77
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 4

<400>  77

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  78
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  78

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  79
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Ala 
            20                  25                  30  


<210>  80
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Arg Ser Ile Leu Asp 
            20                  25                  30  


<210>  81
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 1

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn 
            20                  25                  30  


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 1

<400>  82

Gly Tyr Trp Met Tyr 
1               5   


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 1

<400>  83

Ser Tyr Ser Met Gly 
1               5   


<210>  84
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 1

<400>  84

Phe Asn Ala Met Gly 
1               5   


<210>  85
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 1

<400>  85

Val Met Gly 
1           


<210>  86
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 2

<400>  86

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  87
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 2

<400>  87

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val Thr 
1               5                   10                  


<210>  88
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 2

<400>  88

Ala Ile Ser Pro Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  89
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 2

<400>  89

Ala Ile Ser Trp Ser Gly Asp Glu Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  90
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 2

<400>  90

Thr Ile Ala Arg Ala Gly Ala Thr Lys Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  91
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 2

<400>  91

Ala Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp 
1               5                   10                  15      


Ser Val Lys Ser 
            20  


<210>  92
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  92

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  93
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  93

Arg Phe Thr Ile Ala Arg Gly Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Gly 
            20                  25                  30          


<210>  94
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  94

Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Asn Ala 
            20                  25                  30          


<210>  95
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 3

<400>  95

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Glu 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  96
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3

<400>  96

Ser Leu Thr Ala Thr His Thr Tyr Glu Tyr Asp Tyr 
1               5                   10          


<210>  97
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3

<400>  97

Asp Arg Trp Trp Arg Pro Ala Gly Leu Gln Trp Asp Tyr 
1               5                   10              


<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3

<400>  98

Arg Val Phe Asp Leu Pro Asn Asp Tyr 
1               5                   


<210>  99
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3

<400>  99

Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp Gly Tyr Asp Phe 
1               5                   10                  15  


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Framework 4

<400>  100

Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  101
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn Val Met 
            20                  25                  30          


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
        35                  40                  45              


Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp Gly Tyr 
            100                 105                 110         


Asp Phe Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    130                 135                 140                 


Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser 
145                 150                 155                 160 


Gly Arg Ala Phe Ser Arg Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro 
                165                 170                 175     


Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Gly Trp Gly Pro Ser Lys 
            180                 185                 190         


Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        195                 200                 205             


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu 
    210                 215                 220                 


Asp Thr Ala Val Tyr Ser Cys Ala Ala Lys Phe Val Asn Thr Asp Ser 
225                 230                 235                 240 


Thr Trp Ser Arg Ser Glu Met Tyr Thr Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser 
            260     


<210>  102
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  102

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn Val Met 
            20                  25                  30          


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
        35                  40                  45              


Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp Gly Tyr 
            100                 105                 110         


Asp Phe Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Leu Val Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     


Arg Ala Phe Ser Arg Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Glu Arg Glu Phe Val Ala Ala Ile Gly Trp Gly Pro Ser Lys Thr 
        195                 200                 205             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Ser Cys Ala Ala Lys Phe Val Asn Thr Asp Ser Thr 
                245                 250                 255     


Trp Ser Arg Ser Glu Met Tyr Thr Tyr Trp Gly Gln Gly Thr Gln Val 
            260                 265                 270         


Thr Val Ser Ser 
        275     


<210>  103
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  103

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn Val Met 
            20                  25                  30          


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
        35                  40                  45              


Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp Gly Tyr 
            100                 105                 110         


Asp Phe Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            180                 185                 190         


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        195                 200                 205             


Ala Ala Ile Gly Trp Gly Pro Ser Lys Thr Asn Tyr Ala Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                245                 250                 255     


Ala Ala Lys Phe Val Asn Thr Asp Ser Thr Trp Ser Arg Ser Glu Met 
            260                 265                 270         


Tyr Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        275                 280                 285     


<210>  104
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  104

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Gly Pro Ser Lys Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Lys Phe Val Asn Thr Asp Ser Thr Trp Ser Arg Ser Glu Met 
            100                 105                 110         


Tyr Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    130                 135                 140                 


Gly Ser Val Gln Pro Gly Gly Ser Leu Thr Leu Ser Cys Gly Thr Ser 
145                 150                 155                 160 


Gly Arg Thr Phe Asn Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Glu Arg Glu Phe Val Ala Ala Val Arg Trp Ser Ser Thr Gly Ile Tyr 
            180                 185                 190         


Tyr Thr Gln Tyr Ala Asp Ser Val Lys Ser Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ala Lys Asn Thr Val Tyr Leu Glu Met Asn Ser Leu Lys Pro 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Thr Tyr Asn Ser Asn 
225                 230                 235                 240 


Pro Ala Arg Trp Asp Gly Tyr Asp Phe Arg Gly Gln Gly Thr Gln Val 
                245                 250                 255     


Thr Val Ser Ser 
            260 


<210>  105
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  105

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Gly Pro Ser Lys Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Lys Phe Val Asn Thr Asp Ser Thr Trp Ser Arg Ser Glu Met 
            100                 105                 110         


Tyr Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Ser Val Gln Pro Gly Gly Ser Leu Thr Leu Ser Cys Gly Thr Ser 
                165                 170                 175     


Gly Arg Thr Phe Asn Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Glu Arg Glu Phe Val Ala Ala Val Arg Trp Ser Ser Thr Gly Ile Tyr 
        195                 200                 205             


Tyr Thr Gln Tyr Ala Asp Ser Val Lys Ser Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Ala Lys Asn Thr Val Tyr Leu Glu Met Asn Ser Leu Lys Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Thr Tyr Asn Ser Asn 
                245                 250                 255     


Pro Ala Arg Trp Asp Gly Tyr Asp Phe Arg Gly Gln Gly Thr Gln Val 
            260                 265                 270         


Thr Val Ser Ser 
        275     


<210>  106
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  106

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Gly Pro Ser Lys Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Lys Phe Val Asn Thr Asp Ser Thr Trp Ser Arg Ser Glu Met 
            100                 105                 110         


Tyr Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly 
                165                 170                 175     


Gly Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn Val 
            180                 185                 190         


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
        195                 200                 205             


Ala Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
225                 230                 235                 240 


Val Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                245                 250                 255     


Tyr Cys Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp Gly 
            260                 265                 270         


Tyr Asp Phe Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        275                 280                 285     


<210>  107
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  107

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Arg Thr Ser Ser Tyr Ala 
            20                  25                  30          


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Gly 
        35                  40                  45              


Thr Ile Ser Arg Thr Asn Ser Arg Thr Lys Tyr Ala Asp Phe Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Ser Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Lys Trp Thr Gly Asn Ser Tyr His Asp Tyr Thr Trp Ser Lys Val 
            100                 105                 110         


Asp Glu Tyr Asn Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly 
                165                 170                 175     


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            180                 185                 190         


Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
225                 230                 235                 240 


Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly 
        275                 280                 285             


Gly Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn Val 
    290                 295                 300                 


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
305                 310                 315                 320 


Ala Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp 
                325                 330                 335     


Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
            340                 345                 350         


Val Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
        355                 360                 365             


Tyr Cys Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp Gly 
    370                 375                 380                 


Tyr Asp Phe Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395             


<210>  108
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  108

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Leu Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Ser Pro Thr His Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Gly Lys Asn Thr Val Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Tyr Ser Ser Arg Asp Ala Ala Tyr Arg Ser Asp Tyr Asp 
            100                 105                 110         


Tyr Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
    130                 135                 140                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
                165                 170                 175     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
            180                 185                 190         


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
225                 230                 235                 240 


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
            260                 265                 270         


Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly Ser 
        275                 280                 285             


Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn Val Met Gly 
    290                 295                 300                 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Val 
305                 310                 315                 320 


Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
            340                 345                 350         


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp Gly Tyr Asp 
    370                 375                 380                 


Phe Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395     


<210>  109
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  109

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Gly Pro Ser Lys Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Lys Phe Val Asn Thr Asp Ser Thr Trp Ser Arg Ser Glu Met 
            100                 105                 110         


Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
    130                 135                 140                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
                165                 170                 175     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
            180                 185                 190         


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
225                 230                 235                 240 


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
            260                 265                 270         


Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly Ser 
        275                 280                 285             


Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn Val Met Gly 
    290                 295                 300                 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Val 
305                 310                 315                 320 


Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp Ser Val 
                325                 330                 335     


Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
            340                 345                 350         


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
        355                 360                 365             


Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp Gly Tyr Asp 
    370                 375                 380                 


Phe Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390                 395     


<210>  110
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  110

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Gly Pro Ser Lys Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Lys Phe Val Asn Thr Asp Ser Thr Trp Ser Arg Ser Glu Met 
            100                 105                 110         


Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
    130                 135                 140                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn Ser Leu Arg 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
                165                 170                 175     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
            180                 185                 190         


Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Ile Gly 
225                 230                 235                 240 


Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


<210>  111
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  111

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  112
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  112

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  113
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  113

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  114
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  114

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  115
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  115

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  116
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  116

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  117
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  117

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  118
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  118

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  119
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  119

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala 
        115         


<210>  120
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  120

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala Ala 
        115             


<210>  121
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  121

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly 
        115     


<210>  122
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  122

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly 
        115         


<210>  123
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Sequence

<400>  123

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly 
        115             


<210>  124
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 1

<400>  124

Ser Phe Gly Met Ser 
1               5   


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 2

<400>  125

Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  126
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR 3

<400>  126

Gly Gly Ser Leu Ser Arg 
1               5       


<210>  127
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  127

Gly Gly Gly Gly Ser 
1               5   


<210>  128
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  128

Ser Gly Gly Ser Gly Gly Ser 
1               5           


<210>  129
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  129

Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  130

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  131
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  131

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  132
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  132

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  133
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  133

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  134
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  134

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  135
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  135

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  136
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  136

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


