(19)

(11)

EP 3 277 721 A1

(12)

(43) Date of publication: 07.02.2018 Bulletin 2018/06 (21) Application number: 16713273.7 (22) Date of filing: 24.03.2016

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) A61P 37/00(2006.01) C07K 16/46(2006.01) A61K 39/00(2006.01) (86) International application number: PCT/US2016/023902 (87) International publication number: WO 2016/160476 (06.10.2016 Gazette 2016/40)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 03.04.2015 US 201562142706 P (71) Applicant: Eli Lilly and Company Indianapolis, IN 46285 (US)	(72) Inventors: ALLAN, Barrett Indianapolis, Indiana 46206-6288 (US) KIKLY, Kristine Kay Indianapolis, Indiana 46206-6288 (US) WITCHER, Derrick Ryan Indianapolis, Indiana 46206-6288 (US) (74) Representative: Kent, Lindsey Ruth  Eli Lilly and Company Limited Lilly Research Center Erl Wood Manor Sunninghill Road Windlesham Surrey GU20 6PH Windlesham Surrey GU20 6PH (GB)