(19)

(11)

EP 3 277 831 A2

(12)

(88) Date of publication A3: 24.11.2016 (43) Date of publication: 07.02.2018 Bulletin 2018/06 (21) Application number: 16774179.2 (22) Date of filing: 31.03.2016

(51) International Patent Classification (IPC):  C12Q 1/04(2006.01) G01N 33/569(2006.01) G01N 33/554(2006.01) (86) International application number: PCT/US2016/025219 (87) International publication number: WO 2016/161088 (06.10.2016 Gazette 2016/40)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 31.03.2015 US 201562140920 P (71) Applicant: Fundamental Solutions Corporation Easton, PA 18042 (US)	(72) Inventors: ZUPANCIC, Thomas, J. Powell, OH 43065 (US) ZENG, Lingchun Upper Arlington, OH 43221 (US) VEDAMOORTHY, Srikanth New Albany, OH 43054 (US) LWANDE, Joel, S. Athens, OH 45701 (US) KITTLE, Joseph, D. The Plains, OH 45780 (US) MO, Min Dublin, Ohio 43107 (US) (74) Representative: Samson & Partner Patentanwälte mbB  Widenmayerstraße 6 80538 München 80538 München (DE)