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EP 3 280 420 A1

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(43) Date of publication: 14.02.2018 Bulletin 2018/07 (21) Application number: 16777382.9 (22) Date of filing: 08.04.2016

(51) International Patent Classification (IPC):  A61K 31/57(2006.01) C07J 7/00(2006.01) A61P 25/00(2006.01) (86) International application number: PCT/US2016/026705 (87) International publication number: WO 2016/164763 (13.10.2016 Gazette 2016/41)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 10.04.2015 US 201562146034 P 24.07.2015 US 201562196591 P 20.01.2016 US 201662280825 P (71) Applicant: Sage Therapeutics, Inc. Cambridge, MA 02142 (US)	(72) Inventors: ROBICHAUD, Albert, Jean Cambridge, MA 02141 (US) SALITURO, Francesco, G. Marlborough, MA 01752 (US) MARTINEZ BOTELLA, Gabriel Wayland, MA 01778 (US) HARRISON, Boyd, L. Princeton Junction, NJ 08550 (US) JONAS, Jeffrey Cambridge, MA (US) (74) Representative: Hucker, Charlotte Jane et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL London WC1X 8NL (GB)