(19)
(11) EP 3 283 643 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
10.06.2020 Bulletin 2020/24

(45) Mention of the grant of the patent:
15.04.2020 Bulletin 2020/16

(21) Application number: 16717131.3

(22) Date of filing: 15.04.2016
(51) International Patent Classification (IPC): 
C12Q 1/6895(2018.01)
C12Q 1/6883(2018.01)
(86) International application number:
PCT/EP2016/058355
(87) International publication number:
WO 2016/166287 (20.10.2016 Gazette 2016/42)

(54)

MEANS FOR DIAGNOSING, PREDICTING OR MONITORING PNEUMOCYSTIS PNEUMONIA

MITTEL ZUR DIAGNOSE, PROGNOSE ODER ÜBERWACHUNG VON PNEUMOCYSTIS-PNEUMONIE

MOYENS POUR DIAGNOSTIQUER, PRÉVOIR OU SURVEILLER LA PNEUMONIE À PNEUMOCYSTIS


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 15.04.2015 EP 15305562

(43) Date of publication of application:
21.02.2018 Bulletin 2018/08

(73) Proprietors:
  • Institut Pasteur
    75724 Paris Cedex 15 (FR)
  • Assistance Publique-Hôpitaux de Paris
    75004 Paris (FR)
  • Université de Paris
    75006 Paris (FR)

(72) Inventors:
  • ALANIO, Alexandre
    92340 Bourg-La-Reine (FR)
  • BRETAGNE, Stéphane
    91370 Verrieres Le Buisson (FR)
  • DROMER, Françoise
    75116 Paris (FR)
  • STURNY-LECLERE, Aude
    28320 Ecrosnes (FR)
  • HOMMEL, Benjamin
    75020 Paris (FR)
  • BENAZRA, Marion
    91220 Bretigny Sur Orge (FR)

(74) Representative: Ernest Gutmann - Yves Plasseraud S.A.S. 
66, rue de la Chaussée d'Antin
75009 Paris
75009 Paris (FR)


(56) References cited: : 
WO-A1-2014/071946
WO-A2-2010/039819
   
  • JEONG HWAN SHIN ET AL: "Detection, Identification, and Distribution of Fungi in Bronchoalveolar Lavage Specimens by Use of Multilocus PCR Coupled with Electrospray Ionization/Mass Spectrometry", JOURNAL OF CLINICAL MICROBIOLOGY, vol. 51, no. 1, 24 October 2012 (2012-10-24), pages 136-141, XP055213802, ISSN: 0095-1137, DOI: 10.1128/JCM.01907-12
  • ALANIO ET AL.: "Real-time PCR assay-based strategy for differentiation between active Pneumocystis jirovecii pneumonia and colonization in immunocompromised patients", CLIN MICROBIOL INFECT, vol. 17, 2011, pages 1531-7, XP055214403, cited in the application
  • REVATHY M ET AL: "Evaluation of PCR based DNA sequencing targeting mitochondrial larger subunit (mtLSU) region for the rapid detection of Pneumocystis jirovecii in sputum from HIV positive patients", BMC INFECTIOUS DISEASES, BIOMED CENTRAL, LONDON, GB, vol. 12, no. Suppl 1, 4 May 2012 (2012-05-04), page P78, XP021124868, ISSN: 1471-2334, DOI: 10.1186/1471-2334-12-S1-P78
  • Nicaise G Tuikue Ndam ET AL: "Development of a Real-Time PCR-Based Fluorescence Assay for Rapid Detection of Point Mutations in Pneumocystis jirovecii Dihydropteroate Synthase Gene", J. EUKARYOT. MICROBIOL, 1 January 2003 (2003-01-01), pages 658-660, XP055072548, Retrieved from the Internet: URL:http://onlinelibrary.wiley.com/store/1 0.1111/j.1550-7408.2003.tb00674.x/asset/j. 1550-7408.2003.tb00674.x.pdf?v=1&t=hjh59hd i&s=891d6b3d01795b2d3424e0b8841932e389de81 7c [retrieved on 2013-07-23]
  • L. MA ET AL: "Sequencing and characterization of the complete mitochondrial genomes of three Pneumocystis species provide new insights into divergence between human and rodent Pneumocystis", THE FASEB JOURNAL, vol. 27, no. 5, 7 February 2013 (2013-02-07), pages 1962-1972, XP055214658, ISSN: 0892-6638, DOI: 10.1096/fj.12-224444
  • CHARLES F. THOMAS ET AL: "Current insights into the biology and pathogenesis of Pneumocystis pneumonia", NATURE REVIEWS MICROBIOLOGY, vol. 5, no. 4, 1 April 2007 (2007-04-01), pages 298-308, XP055214733, ISSN: 1740-1526, DOI: 10.1038/nrmicro1621
   
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