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EP 3 288 558 A1

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(43) Date of publication: 07.03.2018 Bulletin 2018/10 (21) Application number: 16723280.0 (22) Date of filing: 29.04.2016

(51) International Patent Classification (IPC):  A61K 31/4439(2006.01) A61K 31/496(2006.01) A61K 31/4985(2006.01) A61K 31/506(2006.01) A61K 31/5377(2006.01) C07D 401/12(2006.01) A61P 35/00(2006.01) A61K 31/454(2006.01) A61K 31/497(2006.01) A61K 31/505(2006.01) A61K 31/519(2006.01) A61K 31/55(2006.01) A61P 35/02(2006.01) (86) International application number: PCT/EP2016/059576 (87) International publication number: WO 2016/174183 (03.11.2016 Gazette 2016/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 30.04.2015 EP 15166016 25.01.2016 EP 16152499 (71) Applicant: Bayer Pharma Aktiengesellschaft 13353 Berlin (DE)

(72) Inventors: BOTHE, Ulrich 13187 Berlin (DE) WENGNER, Antje Margret 13189 Berlin (DE) SIEBENEICHER, Holger 10557 Berlin (DE) SCHMIDT, Nicole San Francisco, California 94105 (US) NUBBEMEYER, Reinhard 13509 Berlin (DE) BÖMER, Ulf 16548 Glienicke (DE) GÜNTHER, Judith 13187 Berlin (DE) STEUBER, Holger 10115 Berlin (DE) LANGE, Martin 10405 Berlin (DE) STEGMANN, Christian 10437 Berlin (DE) SUTTER, Andreas 13086 Berlin (DE) NEUHAUS, Roland 12157 Berlin (DE) (74) Representative: BIP Patents  c/o Bayer Intellectual Property GmbH Alfred-Nobel-Straße 10 40789 Monheim am Rhein 40789 Monheim am Rhein (DE)