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(11)

EP 3 288 634 A1

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(43) Date of publication: 07.03.2018 Bulletin 2018/10 (21) Application number: 16787023.7 (22) Date of filing: 27.04.2016

(51) International Patent Classification (IPC):  A61N 5/00(2006.01) A61N 5/06(2006.01) A61N 5/01(2006.01) A61N 5/10(2006.01) (86) International application number: PCT/US2016/029458 (87) International publication number: WO 2016/176265 (03.11.2016 Gazette 2016/44)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 27.04.2015 US 201562153417 P (71) Applicant: The Trustees Of Dartmouth College Hanover, NH 03755 (US)

(72) Inventors: ZHANG, Rongxiao Norwich, VT 05055 (US) POGUE, Brian, William Hanover, NH 03755 (US) GLASER, Adam, K. Lebanon, NH 03766 (US) GLADSTONE, David, J. Norwich, VT 05055 (US) JARVIS, Lesley, A. Hanover, NH 03755 (US) ANDREOZZI, Jacqueline, M. West Lebanon, NH 03784 (US) JIANG, Shudong Hanover, NH 03755 (US) DAVIS, Scott, Christian Woodsville, NH 03785 (US) AXELSSON, Johan, Jakob 22651 Lund (SE) (74) Representative: m patent group  Postfach 33 04 29 80064 München 80064 München (DE)