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EP 3 298 383 A1

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(43) Date of publication: 28.03.2018 Bulletin 2018/13 (21) Application number: 16842910.8 (22) Date of filing: 31.08.2016

(51) International Patent Classification (IPC):  G01N 21/17(2006.01) G01N 33/48(2006.01) G01N 21/64(2006.01) (86) International application number: PCT/US2016/049708 (87) International publication number: WO 2017/040671 (09.03.2017 Gazette 2017/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 31.08.2015 US 201562211930 P 19.05.2016 US 201615158928 (71) Applicants: Invicro LLC Boston, Massachusetts 02210 (US) Curadel, LLC Marlborough, MA 01752 (US)

(72) Inventors: HOPPIN, John, W. Boston, MA 02127 (US) FRANGIONI, John, V. Worcester, MA 01605 (US) HOLT, Robert, William Boston, MA 02128 (US) QUTAISH, Mohammed, Q. Medford, MA 02155 (US) SEAMAN, Marc, Edward Norwood, MA 02062 (US) BORDO, Mark, W. Worcester, MA 01610 (US) HESTERMAN, Jacob, Yost Newton, MA 02458 (US) (74) Representative: Barker Brettell LLP  100 Hagley Road Edgbaston Birmingham B16 8QQ Birmingham B16 8QQ (GB)