(19)
(11) EP 3 302 572 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
24.03.2021 Bulletin 2021/12

(45) Mention of the grant of the patent:
06.01.2021 Bulletin 2021/01

(21) Application number: 16804586.2

(22) Date of filing: 03.06.2016
(51) International Patent Classification (IPC): 
C07D 401/14(2006.01)
A61P 35/00(2006.01)
 C07D 495/14(2006.01)
(86) International application number:
PCT/US2016/035874
(87) International publication number:
WO 2016/197032 (08.12.2016 Gazette 2016/49)

(54)

IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE

IMID-BASIERTE MODULATOREN VON PROTEOLYSE UND ASSOZIIERTE VERFAHREN ZUR VERWENDUNG

MODULATEURS À BASE D'IMIDE DE PROTÉOLYSE ET PROCÉDÉS D'UTILISATION ASSOCIÉS

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 04.06.2015 US 201562171090 P
06.07.2015 US 201514792414

(43) Date of publication of application:
11.04.2018 Bulletin 2018/15

(73) Proprietor: Arvinas Operations, Inc.
New Haven, CT 06511 (US)

(72) Inventors:
  • CREWS, Craig, M.
    New Haven, CT 06511 (US)
  • CREW, Andrew, P.
    Guilford, CT 06437 (US)
  • DONG, Hanqing
    Madison, CT 06443 (US)
  • WANG, Jing
    Milford, CT 06460 (US)
  • QIAN, Yimin
    Plainsboro, NJ 08536 (US)
  • SIU, Kam
    Milford, CT 06461 (US)
  • JIN, Meizhong
    Wellesley, Massachusetts 02481 (US)

(74) Representative: Kasche, André 
Kasche & Partner AG Bühlstrasse 1
8125 Zollikerberg / Zürich
8125 Zollikerberg / Zürich (CH)


(56) References cited: : 
WO-A2-2015/160845
 US-A1- 2014 356 322
   
  • WINTER ET AL.: 'Phthalimide conjugation as a strategy for in vivo target protein degradation' SCIENCE vol. 348, no. 6241, 21 May 2015, pages 1376 - 1381, XP055328122
  • ZENGERLE ET AL.: 'Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4' ACS CHEMICAL BIOLOGY vol. 10, 02 June 2015, pages 1770 - 1777, XP055333869
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).