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(11)

EP 3 307 314 A1

(12)

(43) Date of publication: 18.04.2018 Bulletin 2018/16 (21) Application number: 16730773.5 (22) Date of filing: 10.06.2016

(51) International Patent Classification (IPC):  A61K 39/235(2006.01) C12N 15/861(2006.01) A61K 39/00(2006.01) C07K 14/075(2006.01) A61K 39/12(2006.01) (86) International application number: PCT/EP2016/063297 (87) International publication number: WO 2016/198599 (15.12.2016 Gazette 2016/50)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 12.06.2015 GB 201510357 12.06.2015 WO PCT/EP2015/063248 19.08.2015 GB 201514772 (71) Applicant: GlaxoSmithKline Biologicals S.A. 1330 Rixensart (BE)	(72) Inventors: AMMENDOLA, Virginia 1300 Wavre (BE) COLLOCA, Stefano 1300 Wavre (BE) CORTESE, Riccardo 1300 Wavre (BE) GRAZIOLI, Fabiana 1300 Wavre (BE) NICOSIA, Alfredo 1300 Wavre (BE) VITELLI, Alessandra 1300 Wavre (BE) (74) Representative: Thornley, Rachel Mary  GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)