(19)

(11)

EP 3 308 113 A2

(12)

(88) Date of publication A3: 13.04.2017 (43) Date of publication: 18.04.2018 Bulletin 2018/16 (21) Application number: 16842459.6 (22) Date of filing: 10.06.2016

(51) International Patent Classification (IPC):  G01J 1/04(2006.01) G01J 1/58(2006.01) G01J 1/42(2006.01) (86) International application number: PCT/US2016/037056 (87) International publication number: WO 2017/039774 (09.03.2017 Gazette 2017/10)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 11.06.2015 US 201562174015 P (71) Applicants: University of Florida Research Foundation, Incorporated Gainesville, Florida 32611 (US) Nanoholdings, LLC Rowayton, CT 06853 (US)

(72) Inventors: SO, Franky Cary, NC 27518 (US) KIM, Do, Young Jenks, OK 74037 (US) LEE, Jae, Woong Raleigh, NC 27604 (US) PRADHAN, Bhabendra, K. Marietta, GA 30066 (US) (74) Representative: Potter Clarkson LLP  The Belgrave Centre Talbot Street Nottingham NG1 5GG Nottingham NG1 5GG (GB)