(19)
(11) EP 3 311 140 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.04.2021 Bulletin 2021/16

(45) Mention of the grant of the patent:
25.11.2020 Bulletin 2020/48

(21) Application number: 16812602.7

(22) Date of filing: 20.06.2016
(51) International Patent Classification (IPC): 
G01N 21/552(2014.01)
G01N 33/543(2006.01)
G01N 21/47(2006.01)
(86) International application number:
PCT/US2016/038308
(87) International publication number:
WO 2016/205775 (22.12.2016 Gazette 2016/51)

(54)

DETERMINING EXTRACELLULAR ANALYTE CONCENTRATION WITH NANOPLASMONIC SENSORS

BESTIMMUNG DER KONZENTRATION VON EXTRAZELLULÄREN ANALYTEN MIT NANOPLASMONISCHEN SENSOREN

DÉTERMINATION D'UNE CONCENTRATION D'ANALYTE EXTRACELLULAIRE AVEC DES CAPTEURS NANOPLASMONIQUES


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 19.06.2015 US 201562181939 P

(43) Date of publication of application:
25.04.2018 Bulletin 2018/17

(73) Proprietor: The Government of the United States of America as represented by the Secretary of the Navy
Arlington, Virginia 22203 (US)

(72) Inventors:
  • RAPHAEL, Marc P.
    Washington, DC 20375 (US)
  • CHRISTODOULIDES, Joseph A.
    Alexandria, VA 22315 (US)
  • BYERS, Jeff M.
    Fairfax Station, VA 22039 (US)
  • DELEHANTY, James B.
    Washington, DC 20002 (US)

(74) Representative: De Vries & Metman 
Overschiestraat 180
1062 XK Amsterdam
1062 XK Amsterdam (NL)


(56) References cited: : 
WO-A2-2005/026701
US-A1- 2012 105 853
US-A1- 2014 095 100
US-A1- 2014 273 002
US-A1- 2011 116 093
US-A1- 2014 095 100
US-A1- 2014 273 002
   
  • RAPHAEL MARC P ET AL: "Quantitative Imaging of Protein Secretions from Single Cells in Real Time", BIOPHYSICAL JOURNAL, vol. 105, no. 3, August 2013 (2013-08), pages 602-608, XP028690015, ISSN: 0006-3495, DOI: 10.1016/J.BPJ.2013.06.022
  • MARC P. RAPHAEL ET AL: "A New Methodology for Quantitative LSPR Biosensing and Imaging", ANALYTICAL CHEMISTRY, vol. 84, no. 3, 7 February 2012 (2012-02-07), pages 1367-1373, XP055103438, ISSN: 0003-2700, DOI: 10.1021/ac2023266
  • J. ORTEGA ARROYO ET AL: "Label-Free, All-Optical Detection, Imaging, and Tracking of a Single Protein", NANO LETTERS, vol. 14, no. 4, 9 April 2014 (2014-04-09), pages 2065-2070, XP055269011, US ISSN: 1530-6984, DOI: 10.1021/nl500234t
   
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