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EP 3 313 371 A2

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(88) Date of publication A3: 16.03.2017 (43) Date of publication: 02.05.2018 Bulletin 2018/18 (21) Application number: 16738302.5 (22) Date of filing: 24.06.2016

(51) International Patent Classification (IPC):  A61K 9/00(2006.01) A61K 35/745(2015.01) A23L 33/135(2016.01) A61K 35/744(2015.01) A61K 35/747(2015.01) (86) International application number: PCT/US2016/039444 (87) International publication number: WO 2016/210384 (29.12.2016 Gazette 2016/52)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 25.06.2015 US 201562184777 P 11.01.2016 US 201662277346 P 10.02.2016 US 201662293695 P 13.05.2016 US 201662336012 P 13.05.2016 WO PCT/US2016/032565 08.06.2016 US 201662347576 P 08.06.2016 US 201662347554 P 08.06.2016 US 201662347508 P 10.06.2016 US 201662348620 P 10.06.2016 US 201662348416 P (71) Applicant: Synlogic, Inc. Cambridge, MA 02139 (US)

(72) Inventors: FALB, Dean Sherborn, MA 01770 (US) ISABELLA, Vincent, M. Cambridge, MA 02139 (US) KOTULA, Jonathan, W. Somerville, MA 02143 (US) MILLER, Paul, F. Salem, CT 06420 (US) ROWE, Sarah Durham, NC 27707 (US) MILLET, Yves Newton, MA 02460 (US) FISHER, Adam Cambridge, MA 02139 (US) (74) Representative: Murgitroyd & Company  Scotland House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)