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(11)

EP 3 317 246 A2

(12)

(88) Date of publication A3: 02.06.2016 (43) Date of publication: 09.05.2018 Bulletin 2018/19 (21) Application number: 15772625.8 (22) Date of filing: 04.07.2015

(51) International Patent Classification (IPC):  C07C 59/76(2006.01) C07D 417/14(2006.01) C07K 16/28(2006.01) A61K 45/06(2006.01) A61P 35/00(2006.01) C07C 237/52(2006.01) C07D 207/46(2006.01) A61K 39/395(2006.01) A61P 31/00(2006.01) A61P 37/00(2006.01) (86) International application number: PCT/IB2015/055051 (87) International publication number: WO 2015/151080 (08.10.2015 Gazette 2015/40)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA (71) Applicant: Suzhou M-conj Biotech Co., Ltd. Suzhou City, Jiangsu 215123 (CN)	(72) Inventor: ZHAO, Robert Yongxin Lexington, MA 02421 (US) (74) Representative: Stafford, Jonathan Alan Lewis  Marks & Clerk LLP 1 New York Street Manchester M1 4HD Manchester M1 4HD (GB)