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EP 3 317 279 A1

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(43) Date of publication: 09.05.2018 Bulletin 2018/19 (21) Application number: 16733538.9 (22) Date of filing: 30.06.2016

(51) International Patent Classification (IPC):  C07D 471/10(2006.01) A61K 31/438(2006.01) C07D 519/00(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/EP2016/065231 (87) International publication number: WO 2017/005583 (12.01.2017 Gazette 2017/02)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 03.07.2015 EP 15175259 (71) Applicant: F. Hoffmann-La Roche AG 4070 Basel (CH)

(72) Inventors: BUETTELMANN, Bernd 4070 Basel (CH) KOCER, Buelent 4070 Basel (CH) KUHN, Bernd 4070 Basel (CH) PRUNOTTO, Marco 4070 Basel (CH) RICHTER, Hans 4070 Basel (CH) RITTER, Martin 4070 Basel (CH) RUDOLPH, Markus 4070 Basel (CH) SATZ, Alexander Lee 4070 Basel (CH) (74) Representative: Schirlin, Julien  F. Hoffmann-La Roche AG CLP - Patent Department Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)