(19)

(11)

EP 3 328 848 A1

(12)

(43) Date of publication: 06.06.2018 Bulletin 2018/23 (21) Application number: 16753812.3 (22) Date of filing: 28.07.2016

(51) International Patent Classification (IPC):  C07D 401/12(2006.01) A61P 35/00(2006.01) A61K 31/506(2006.01) (86) International application number: PCT/CZ2016/000082 (87) International publication number: WO 2017/016529 (02.02.2017 Gazette 2017/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 28.07.2015 CZ 20150522 21.10.2015 CZ 20150743 (71) Applicant: Zentiva, K.S. 102 37 Praha 10 (CZ)	(72) Inventors: ZVATORA, Pavel 198 00 Praha 9-Cerny Most (CZ) DAMMER, Ondrej 253 01 Hostivice (CZ) KREJCIK, Lukas 190 17 Praha 9 (CZ) CERNA, Igor 169 00 Praha 6 (CZ) (74) Representative: Jirotkova, Ivana et al Rott, Ruzicka & Guttmann Patent, Trademark and Law Offices Vinohradskà 37 120 00 Praha 2 120 00 Praha 2 (CZ)