(19)

(11)

EP 3 329 276 A2

(12)

(88) Date of publication A3: 08.06.2017 (43) Date of publication: 06.06.2018 Bulletin 2018/23 (21) Application number: 16750314.3 (22) Date of filing: 26.07.2016

(51) International Patent Classification (IPC):  G01N 33/50(2006.01) (86) International application number: PCT/US2016/044022 (87) International publication number: WO 2017/019673 (02.02.2017 Gazette 2017/05)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 27.07.2015 US 201562197293 P 14.10.2015 US 201562241331 P (71) Applicant: F. Hoffmann-La Roche AG 4070 Basel (CH)	(72) Inventors: MONTAGUT, Teresa Ramirez South San Francisco, California 94080 (US) CHAI, Akiko South San Francisco, California 94080 (US) FUH, Franklin South San Francisco, California 94080 (US) (74) Representative: Heiroth, Ulrike Hildegard  F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124 4070 Basel 4070 Basel (CH)