(19)
(11) EP 3 330 729 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
25.10.2023 Bulletin 2023/43

(45) Mention of the grant of the patent:
28.06.2023 Bulletin 2023/26

(21) Application number: 16201736.2

(22) Date of filing: 01.12.2016
(51) International Patent Classification (IPC): 
G01R 33/465(2006.01)
G01N 24/08(2006.01)
G01R 33/56(2006.01)
(52) Cooperative Patent Classification (CPC):
G01N 24/08; G01R 33/465; G01R 33/5601; G01R 33/5605

(54)

NMR METHOD FOR QUANTITATIVELY DETERMINING AN ANALYTE IN A LIQUID SAMPLE USING A HYPERPOLARIZED GAS

NMR-VERFAHREN FÜR DEN QUANTITATIVEN NACHWEIS EINES ANALYTEN IN EINER FLÜSSIGPROBE UNTER VERWENDUNG EINES HYPERPOLARISIERTEN GASES

PROCÉDÉ PAR RMN D'IDENTIFICATION D'UN ANALYTE DANS UN ÉCHANTILLON DE FLUIDE UTILISANT UN GAS HYPERPOLARISÉ


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(43) Date of publication of application:
06.06.2018 Bulletin 2018/23

(73) Proprietor: Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Technologie, dieses vertreten durch den Präsidenten
38116 Braunschweig (DE)

(72) Inventors:
  • Mitschang, Lorenz
    10119 Berlin (DE)
  • Kilian, Wolfgang
    12355 Berlin (DE)
  • Korchak, Sergey
    10587 Berlin (DE)

(74) Representative: Bittner, Thomas L. et al
Boehmert & Boehmert Anwaltspartnerschaft mbB Pettenkoferstrasse 22
80336 München
80336 München (DE)


(56) References cited: : 
   
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  • TYLER MELDRUM ET AL: "Band-selective chemical exchange saturation transfer imaging with hyperpolarized xenon-based molecular sensors", JOURNAL OF MAGNETIC RESONANCE, vol. 213, no. 1, 13 July 2011 (2011-07-13) , pages 14-21, XP028331581, ISSN: 1090-7807, DOI: 10.1016/J.JMR.2011.06.027 [retrieved on 2011-07-13]
  • TODD K. STEVENS ET AL: "HyperCEST detection of a 129 Xe-based contrast agent composed of cryptophane-A molecular cages on a bacteriophage scaffold", MAGNETIC RESONANCE IN MEDICINE., vol. 69, no. 5, 12 May 2013 (2013-05-12), pages 1245-1252, XP055322762, US ISSN: 0740-3194, DOI: 10.1002/mrm.24371
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  • YUBIN BAI ET AL: "Bacterial spore detection and analysis using hyperpolarized 129Xe chemical exchange saturation transfer (Hyper-CEST) NMR", CHEMICAL SCIENCE, vol. 5, no. 8, 22 May 2014 (2014-05-22), pages 3197-3203, XP055371274, United Kingdom ISSN: 2041-6520, DOI: 10.1039/c4sc01190b
  • KORCHAK SERGEY ET AL: "Design and comparison of exchange spectroscopy approaches to cryptophane-xenon host-guest kinetics", JOURNAL OF MAGNETIC RESONANCE, ACADEMIC PRESS, ORLANDO, FL, US, vol. 265, 12 February 2016 (2016-02-12), pages 139-145, XP029486241, ISSN: 1090-7807, DOI: 10.1016/J.JMR.2016.02.005
  • YUBIN BAI ET AL: "Utilizing a Water-Soluble Cryptophane with Fast Xenon Exchange Rates for Picomolar Sensitivity NMR Measurements", ANALYTICAL CHEMISTRY, vol. 84, no. 22, 29 October 2012 (2012-10-29), pages 9935-9941, XP055371055, US ISSN: 0003-2700, DOI: 10.1021/ac302347y
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  • SCHR\DER L ET AL: "Molecular imaging using a targeted magnetic resonance hyperpolarized biosensor", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, vol. 314, 20 October 2006 (2006-10-20), pages 446-449, XP002476683, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.1131847
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