<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE ep-patent-document PUBLIC "-//EPO//EP PATENT DOCUMENT 1.6//EN" "ep-patent-document-v1-6.dtd">
<!-- This XML data has been generated under the supervision of the European Patent Office -->
<ep-patent-document id="EP16201736B8W1" file="EP16201736W1B8.xml" lang="en" country="EP" doc-number="3330729" kind="B8" correction-code="W1" date-publ="20231025" status="c" dtd-version="ep-patent-document-v1-6">
<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHUPLSK..HRIS..MTNORS..SM..................</B001EP><B005EP>J</B005EP><B007EP>BDM Ver 2.0.24 -  2999001/0</B007EP></eptags></B000><B100><B110>3330729</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20231025</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>16201736.2</B210><B220><date>20161201</date></B220><B240><B241><date>20190312</date></B241><B242><date>20210624</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B400><B405><date>20231025</date><bnum>202343</bnum></B405><B430><date>20180606</date><bnum>201823</bnum></B430><B450><date>20230628</date><bnum>202326</bnum></B450><B452EP><date>20230214</date></B452EP><B480><date>20231025</date><bnum>202343</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>G01R  33/465       20060101AFI20170524BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>G01R  33/56        20060101ALI20170524BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>G01N  24/08        20060101ALI20170524BHEP        </text></classification-ipcr></B510EP><B520EP><classifications-cpc><classification-cpc sequence="1"><text>G01N  24/08        20130101 LI20170510BHEP        </text></classification-cpc><classification-cpc sequence="2"><text>G01R  33/465       20130101 FI20170509BHEP        </text></classification-cpc><classification-cpc sequence="3"><text>G01R  33/5601      20130101 LI20170509BHEP        </text></classification-cpc><classification-cpc sequence="4"><text>G01R  33/5605      20130101 LI20170509BHEP        </text></classification-cpc></classifications-cpc></B520EP><B540><B541>de</B541><B542>NMR-VERFAHREN FÜR DEN QUANTITATIVEN NACHWEIS EINES ANALYTEN IN EINER FLÜSSIGPROBE UNTER VERWENDUNG EINES HYPERPOLARISIERTEN GASES</B542><B541>en</B541><B542>NMR METHOD FOR QUANTITATIVELY DETERMINING AN ANALYTE IN A LIQUID SAMPLE USING A HYPERPOLARIZED GAS</B542><B541>fr</B541><B542>PROCÉDÉ PAR RMN D'IDENTIFICATION D'UN ANALYTE DANS UN ÉCHANTILLON DE FLUIDE UTILISANT UN GAS HYPERPOLARISÉ</B542></B540><B560><B562><text>MARTIN KUNTH ET AL: "Identification, classification, and signal amplification capabilities of high-turnover gas binding hosts in ultra-sensitive NMR", CHEMICAL SCIENCE, vol. 6, no. 11, 6 July 2015 (2015-07-06), pages 6069-6075, XP055371705, United Kingdom ISSN: 2041-6520, DOI: 10.1039/C5SC01400J</text></B562><B562><text>ZAISS M ET AL: "Analytical solution for the depolarization of hyperpolarized nuclei by chemical exchange saturation transfer between free and encapsulated xenon (HyperCEST)", JOURNAL OF CHEMICAL PHYSICS, AMERICAN INSTITUTE OF PHYSICS, US, vol. 136, no. 14, 14 April 2012 (2012-04-14), pages 144106-1, XP009194353, ISSN: 0021-9606, DOI: 10.1063/1.3701178</text></B562><B562><text>M. KUNTH ET AL: "Quantitative chemical exchange saturation transfer with hyperpolarized nuclei (qHyper-CEST): Sensing xenon-host exchange dynamics and binding affinities by NMR", JOURNAL OF CHEMICAL PHYSICS, vol. 141, no. 19, 21 November 2014 (2014-11-21), page 194202, XP055372198, US ISSN: 0021-9606, DOI: 10.1063/1.4901429</text></B562><B562><text>YANFEI WANG ET AL: "An Expanded Palette of Xenon-129 NMR Biosensors", ACCOUNTS OF CHEMICAL RESEARCH., vol. 49, no. 10, 19 September 2016 (2016-09-19), pages 2179-2187, XP055371283, US ISSN: 0001-4842, DOI: 10.1021/acs.accounts.6b00309</text></B562><B562><text>TYLER MELDRUM ET AL: "Band-selective chemical exchange saturation transfer imaging with hyperpolarized xenon-based molecular sensors", JOURNAL OF MAGNETIC RESONANCE, vol. 213, no. 1, 13 July 2011 (2011-07-13) , pages 14-21, XP028331581, ISSN: 1090-7807, DOI: 10.1016/J.JMR.2011.06.027 [retrieved on 2011-07-13]</text></B562><B562><text>TODD K. STEVENS ET AL: "HyperCEST detection of a 129 Xe-based contrast agent composed of cryptophane-A molecular cages on a bacteriophage scaffold", MAGNETIC RESONANCE IN MEDICINE., vol. 69, no. 5, 12 May 2013 (2013-05-12), pages 1245-1252, XP055322762, US ISSN: 0740-3194, DOI: 10.1002/mrm.24371</text></B562><B562><text>LEIF SCHRÖDER: "Xenon for NMR biosensing - Inert but alert", PHYSICA MEDICA, vol. 29, no. 1, 26 November 2011 (2011-11-26), pages 3-16, XP055371291, IT ISSN: 1120-1797, DOI: 10.1016/j.ejmp.2011.11.001</text></B562><B562><text>YUBIN BAI ET AL: "Bacterial spore detection and analysis using hyperpolarized 129Xe chemical exchange saturation transfer (Hyper-CEST) NMR", CHEMICAL SCIENCE, vol. 5, no. 8, 22 May 2014 (2014-05-22), pages 3197-3203, XP055371274, United Kingdom ISSN: 2041-6520, DOI: 10.1039/c4sc01190b</text></B562><B562><text>KORCHAK SERGEY ET AL: "Design and comparison of exchange spectroscopy approaches to cryptophane-xenon host-guest kinetics", JOURNAL OF MAGNETIC RESONANCE, ACADEMIC PRESS, ORLANDO, FL, US, vol. 265, 12 February 2016 (2016-02-12), pages 139-145, XP029486241, ISSN: 1090-7807, DOI: 10.1016/J.JMR.2016.02.005</text></B562><B562><text>YUBIN BAI ET AL: "Utilizing a Water-Soluble Cryptophane with Fast Xenon Exchange Rates for Picomolar Sensitivity NMR Measurements", ANALYTICAL CHEMISTRY, vol. 84, no. 22, 29 October 2012 (2012-10-29), pages 9935-9941, XP055371055, US ISSN: 0003-2700, DOI: 10.1021/ac302347y</text></B562><B562><text>BARTIK K ET AL: "XE AND H NMR STUDY OF THE REVERSIBLE TRAPPING OF XENON BY CRYPTOPHANE-A IN ORGANIC SOLUTION", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, THE SOCIETY, vol. 120, no. 4, 1 January 1998 (1998-01-01), pages 784-791, XP002905737, ISSN: 0002-7863, DOI: 10.1021/JA972377J</text></B562><B562><text>SCHR\DER L ET AL: "Molecular imaging using a targeted magnetic resonance hyperpolarized biosensor", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, vol. 314, 20 October 2006 (2006-10-20), pages 446-449, XP002476683, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.1131847</text></B562><B562><text>SERGEY KORCHAK ET AL: "Degeneracy in cryptophane-xenon complex formation in aqueous solution", CHEMICAL COMMUNICATIONS - CHEMCOM., vol. 51, no. 9, 17 December 2014 (2014-12-17), pages 1721-1724, XP055371043, ISSN: 1359-7345, DOI: 10.1039/C4CC08601E</text></B562></B560></B500><B700><B720><B721><snm>Mitschang, Lorenz</snm><adr><str>Almstadtstrasse 48</str><city>10119 Berlin</city><ctry>DE</ctry></adr></B721><B721><snm>Kilian, Wolfgang</snm><adr><str>Andreas-Hermes-Siedlung 7</str><city>12355 Berlin</city><ctry>DE</ctry></adr></B721><B721><snm>Korchak, Sergey</snm><adr><str>Eosanderstrasse 30</str><city>10587 Berlin</city><ctry>DE</ctry></adr></B721></B720><B730><B731><snm>Bundesrepublik Deutschland, vertreten durch das 
Bundesministerium für Wirtschaft und Technologie, 
dieses vertreten durch den Präsidenten</snm><iid>102011664</iid><irf>P75068EP</irf><adr><str>der Physikalisch-Technischen Bundesanstalt 
Braunschweig und Berlin 
Bundesallee 100</str><city>38116 Braunschweig</city><ctry>DE</ctry></adr></B731></B730><B740><B741><snm>Bittner, Thomas L.</snm><sfx>et al</sfx><iid>100045424</iid><adr><str>Boehmert &amp; Boehmert 
Anwaltspartnerschaft mbB 
Pettenkoferstrasse 22</str><city>80336 München</city><ctry>DE</ctry></adr></B741></B740></B700><B800><B840><ctry>AL</ctry><ctry>AT</ctry><ctry>BE</ctry><ctry>BG</ctry><ctry>CH</ctry><ctry>CY</ctry><ctry>CZ</ctry><ctry>DE</ctry><ctry>DK</ctry><ctry>EE</ctry><ctry>ES</ctry><ctry>FI</ctry><ctry>FR</ctry><ctry>GB</ctry><ctry>GR</ctry><ctry>HR</ctry><ctry>HU</ctry><ctry>IE</ctry><ctry>IS</ctry><ctry>IT</ctry><ctry>LI</ctry><ctry>LT</ctry><ctry>LU</ctry><ctry>LV</ctry><ctry>MC</ctry><ctry>MK</ctry><ctry>MT</ctry><ctry>NL</ctry><ctry>NO</ctry><ctry>PL</ctry><ctry>PT</ctry><ctry>RO</ctry><ctry>RS</ctry><ctry>SE</ctry><ctry>SI</ctry><ctry>SK</ctry><ctry>SM</ctry><ctry>TR</ctry></B840></B800></SDOBI>
</ep-patent-document>
