(19)

(11)

EP 3 334 417 A1

(12)

(43) Date of publication: 20.06.2018 Bulletin 2018/25 (21) Application number: 16836005.5 (22) Date of filing: 12.08.2016

(51) International Patent Classification (IPC):  A61K 9/127(2006.01) A61K 39/395(2006.01) A61K 39/00(2006.01) (86) International application number: PCT/US2016/046891 (87) International publication number: WO 2017/027843 (16.02.2017 Gazette 2017/07)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 12.08.2015 US 201562204337 P (71) Applicant: Massachusetts Institute of Technology Cambridge, MA 02139 (US)	(72) Inventors: IRVINE, Darrell J. Arlington, MA 02476 (US) ZHENG, Yiran Singapore 649816 (SG) TANG, Li Quincy, MA 02171 (US) (74) Representative: Inspicos P/S  Kogle Allé 2 2970 Hørsholm 2970 Hørsholm (DK)