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<ep-patent-document id="EP18155644B8W1" file="EP18155644W1B8.xml" lang="en" country="EP" doc-number="3351246" kind="B8" correction-code="W1" date-publ="20190918" status="c" dtd-version="ep-patent-document-v1-5">
<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIRO..CY..TR................................................</B001EP><B005EP>J</B005EP><B007EP>BDM Ver 0.1.67 (18 Oct 2017) -  2999001/0</B007EP></eptags></B000><B100><B110>3351246</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20190918</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>18155644.0</B210><B220><date>20020218</date></B220><B240><B241><date>20180207</date></B241><B242><date>20190118</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>0104072</B310><B320><date>20010219</date></B320><B330><ctry>GB</ctry></B330><B310>0124957</B310><B320><date>20011017</date></B320><B330><ctry>GB</ctry></B330></B300><B400><B405><date>20190918</date><bnum>201938</bnum></B405><B430><date>20180725</date><bnum>201830</bnum></B430><B450><date>20190522</date><bnum>201921</bnum></B450><B452EP><date>20190410</date></B452EP><B480><date>20190918</date><bnum>201938</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>A61K  31/436       20060101AFI20180601BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>A61P  35/00        20060101ALI20180601BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>A61P  35/04        20060101ALI20180601BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>RAPAMYCIN-DERIVAT ZUR BEHANDLUNG EINES SOLIDEN TUMORS, DER MIT DEREGULIERTER ANGIOGENESE ASSOZIIERT IST</B542><B541>en</B541><B542>RAPAMYCIN DERIVATIVE FOR THE TREATMENT OF A SOLID TUMOR ASSOCIATED WITH DEREGULATED ANGIOGENESIS</B542><B541>fr</B541><B542>DÉRIVÉ DE RAPAMYCINE POUR LE TRAITEMENT D'UNE TUMEUR SOLIDE ASSOCIÉE À UNE ANGIOGENÈSE DÉRÉGULÉE</B542></B540><B560><B561><text>WO-A1-01/51049</text></B561><B561><text>WO-A1-94/09010</text></B561><B561><text>WO-A1-97/47317</text></B561><B561><text>US-A- 5 206 018</text></B561><B562><text>GUBA M ET AL: "RAPAMYCIN INHIBIERT DAS TUMORWACHTSUM UND DIE TUMORMETASTASIERUNG UEBER ANTIANGIOGENESE//RAPAMYCIN INHIBITS TUMOR GROWTH AND METASTASIS BY ANTIANGIOGENESIS", CHIRURGISCHES FORUM FUER EXPERIMENTELLE UND KLINISCHE FORSCHUNG, BERLIN, DE, 1 January 2001 (2001-01-01), pages 37-39, XP001088707, ISSN: 0303-6227</text></B562><B562><text>SHAH SHIMUL A ET AL: "FRAP-p70s6K Signaling Is Required for Pancreatic Cancer Cell Proliferation", JOURNAL OF SURGICAL RESEARCH, ACADEMIC PRESS INC., SAN DIEGO, CA, US, vol. 97, no. 2, 2 November 2000 (2000-11-02), pages 123-130, XP029590080, ISSN: 0022-4804, DOI: 10.1006/JSRE.2001.6145</text></B562><B562><text>HIDALGO M ET AL: "THE RAPAMYCIN-SENSITIVE SIGNAL TRANSDUCTION PATHWAY AS A TARGET FOR CANCER THERAPY", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 19, no. 56, December 2000 (2000-12), pages 6680-6686, XP009002368, ISSN: 0950-9232, DOI: 10.1038/SJ.ONC.1204091</text></B562><B562><text>SEUFFERLEIN T ET AL: "Constitutive activation of p70s6k in human pancreatic cancer cell lines bearing activating Ki-ras mutations", GASTROENTEROLOGY, W.B. 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ADIS TITLE: CCI 779: therapeutic use Solid tumours Phase I trial", PROGRAM/PROCEEDINGS - AMERICAN SOCIETY OF CLINICAL ONCOLOGY, THE SOCIETY, US, vol. 19, 2000, page 187, XP009193117, ISSN: 1081-0641</text></B562><B562><text>TSUCHIYA N ET AL: "EFFECTS OF FADROZOLE AND LEUPRORELIN ACETATE ON AROMATASE ACTIVITY AND CELL PROLIFERATION IN A HUMAN BREAST CANCER CELL LINE (SK-BR-3)", INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, CHURCHILL LIVINGSTONE JAPAN, TOKYO, GB, vol. 5, 1 January 2000 (2000-01-01), pages 183-187, XP001069645, ISSN: 1341-9625</text></B562><B562><text>BUZDAR A ET AL: "Advances in aromatase inhibition: clinical efficacy and tolerability in the treatment of breast cancer", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 7, no. 9, 1 September 2001 (2001-09-01), pages 2620-2635, XP002784456, ISSN: 1078-0432</text></B562><B562><text>CLEMETT DELYTH ET AL: "Exemestane: A review of its use in postmenopausal women with advanced breast cancer", DRUGS, ADIS INTERNATIONAL LTD, NZ, vol. 59, no. 6, 1 June 2000 (2000-06-01), pages 1279-1296, XP002784405, ISSN: 0012-6667</text></B562><B562><text>GOSS P E ET AL: "Aromatase inhibitors in the treatment and prevention of breast cancer", JOURNAL OF CLINICAL ONCOLOGY, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, US, vol. 19, no. 3, 1 February 2001 (2001-02-01), pages 881-894, XP003022842, ISSN: 0732-183X</text></B562><B562><text>YU K ET AL: "MTOR, A NOVEL TARGET IN BREAST CANCER: THE EFFECT OF CCI-779, AN MTOR INHIBITOR, IN PRECLINICAL MODELS OF BREAST CANCER", ENDOCRINE - RELATED CANCER, BIOSCIENTIFICA LTD, GB, vol. 8, no. 3, 1 September 2001 (2001-09-01), pages 249-258, XP001079023, ISSN: 1351-0088, DOI: 10.1677/ERC.0.0080249</text></B562></B560></B500><B600><B620><parent><pdoc><dnum><anum>16186041.6</anum><pnum>3143995</pnum></dnum><date>20160826</date></pdoc><pdoc><dnum><anum>14164259.5</anum><pnum>2783686</pnum></dnum><date>20140410</date></pdoc><pdoc><dnum><anum>02719864.7</anum><pnum>1363627</pnum></dnum><date>20020218</date></pdoc></parent></B620></B600><B700><B720><B721><snm>Lane, Heidi</snm><adr><str>Kaltbrunnenweg 8</str><city>4106 Therwill</city><ctry>CH</ctry></adr></B721><B721><snm>O`Reilly, Terence</snm><adr><str>Drahtzugstrasse 51</str><city>4057 Basel</city><ctry>CH</ctry></adr></B721><B721><snm>Wood, Jeanette Marjorie</snm><adr><str>In den Kleematten 18</str><city>4105 Biel-Benken</city><ctry>CH</ctry></adr></B721></B720><B730><B731><snm>Novartis Pharma AG</snm><iid>100966220</iid><irf>P073583EP:CJM</irf><adr><str>Lichtstrasse 35</str><city>4056 Basel</city><ctry>CH</ctry></adr></B731><B731><snm>Novartis International Pharmaceutical AG</snm><iid>101823421</iid><irf>P073583EP:CJM</irf><adr><str>Lichtstrasse 35</str><city>4056 Basel</city><ctry>CH</ctry></adr></B731></B730><B740><B741><snm>Carpmaels &amp; Ransford LLP</snm><iid>101299776</iid><adr><str>One Southampton Row</str><city>London WC1B 5HA</city><ctry>GB</ctry></adr></B741></B740><B780><B781><dnum><text>01</text></dnum><date>20190523</date><kind>1</kind><snm>STADA Arzneimittel AG</snm><iid>100705187</iid><adr><str>Stadastrasse 2-18</str><city>61118 Bad Vilbel</city><ctry>DE</ctry></adr><B784><snm>Hamm&amp;Wittkopp Patentanwälte PartmbB</snm><sfx>et al</sfx><iid>101576032</iid><adr><str>Jungfernstieg 38</str><city>20354 Hamburg</city><ctry>DE</ctry></adr></B784></B781><B781><dnum><text>02</text></dnum><date>20190701</date><kind>1</kind><snm>BIOGARAN</snm><iid>101831667</iid><adr><str>15 Boulevard Charles de Gaulle</str><city>92707 COLOMBES</city><ctry>FR</ctry></adr><B784><snm>Casalonga</snm><iid>101339021</iid><adr><str>Casalonga &amp; Partners 
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