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(11)

EP 3 352 792 A1

(12)

(43) Date of publication: 01.08.2018 Bulletin 2018/31 (21) Application number: 16849854.1 (22) Date of filing: 26.09.2016

(51) International Patent Classification (IPC):  A61K 45/00(2006.01) G01N 33/15(2006.01) A61P 11/00(2006.01) (86) International application number: PCT/US2016/053743 (87) International publication number: WO 2017/053952 (30.03.2017 Gazette 2017/13)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 25.09.2015 US 201562232864 P (71) Applicant: Cedars-Sinai Medical Center Los Angeles, CA 90048 (US)	(72) Inventors: NOBLE, Paul, W. Beverly Hills, CA 90210 (US) JIANG, Dianhua Encino, CA 91316 (US) LIANG, Carol, Jiurong Encino, CA 91316 (US) (74) Representative: J A Kemp  14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)