(19)
(11) EP 3 353 203 A2

(12)

(88) Date of publication A3:
26.05.2017

(43) Date of publication:
01.08.2018 Bulletin 2018/31

(21) Application number: 16774827.6

(22) Date of filing: 23.09.2016
(51) International Patent Classification (IPC): 
C07K 16/22(2006.01)
A61K 39/00(2006.01)
(86) International application number:
PCT/US2016/053454
(87) International publication number:
WO 2017/053807 (30.03.2017 Gazette 2017/13)
(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
MA MD

(30) Priority: 23.09.2015 US 201562222698 P
28.12.2015 US 201562271913 P

(71) Applicant: F. Hoffmann-La Roche AG
4070 Basel (CH)

(72) Inventors:
  • KOENIG, Patrick
    San Francisco, CA 94114 (US)
  • LEE, Chingwei, Vivian
    South San Francisco, CA 94080-4990 (US)
  • RAJAGOPAL, Karthikan
    South San Francisco, CA 94080-4990 (US)
  • FAMILI, Amin
    South San Francisco, CA 94080-4990 (US)
  • FUH, Germaine
    Pacifica, CA 94044 (US)

(74) Representative: Winkler, Thomas 
F. Hoffmann-La Roche AG Patent Department Grenzacherstrasse 124
4070 Basel
4070 Basel (CH)

   


(54) OPTIMIZED VARIANTS OF ANTI-VEGF ANTIBODIES