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(11)

EP 3 356 332 A1

(12)

(43) Date of publication: 08.08.2018 Bulletin 2018/32 (21) Application number: 16852356.1 (22) Date of filing: 26.09.2016

(51) International Patent Classification (IPC):  C07D 239/70(2006.01) A61P 25/28(2006.01) A61K 31/517(2006.01) C07D 401/10(2006.01) (86) International application number: PCT/US2016/053652 (87) International publication number: WO 2017/058691 (06.04.2017 Gazette 2017/14)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 30.09.2015 US 201562235061 P (71) Applicants: Merck Sharp & Dohme Corp. Rahway, NJ 07065-0907 (US) Merck Sharp & Dohme Limited Hoddesdon, Hertfordshire EN11 9BU (GB)

(72) Inventors: CHEN, Qinghao Rahway, New Jersey 07065-0907 (US) SCOTT, Jeremy Hoddesdon Hertfordshire EN11 9BU (GB) KRSKA, Shane, W. Rahway, New Jersey 07065-0907 (US) BAXTER, Carl Hoddesdon Hertfordshire EN11 9BU (GB) STEWART, Gavin William Stevenage Hertfordshire SG2 7QF (GB) TAN, Lushi Rahway, New Jersey 07065-0907 (US) GIBB, Andrew Hoddesdon Hertfordshire EN11 9BU (GB) MALIGRES, Peter, E. Rahway, New Jersey 07065-0907 (US) (74) Representative: Jaap, David Robert  MSD Hertford Road Hoddesdon, Herts EN11 9BU Hoddesdon, Herts EN11 9BU (GB)