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EP 3 362 057 A1

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(43) Date of publication: 22.08.2018 Bulletin 2018/34 (21) Application number: 16787982.4 (22) Date of filing: 14.10.2016

(51) International Patent Classification (IPC):  A61K 31/136(2006.01) A61K 31/704(2006.01) A61K 31/7068(2006.01) A61K 31/53(2006.01) A61K 31/7048(2006.01) A61P 35/02(2006.01) (86) International application number: PCT/US2016/057083 (87) International publication number: WO 2017/066599 (20.04.2017 Gazette 2017/16)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 15.10.2015 US 201562242256 P 13.11.2015 US 201562255194 P (71) Applicant: Agios Pharmaceuticals, Inc. Cambridge, MA 02139 (US)	(72) Inventor: AGRESTA, Samuel, V. Lexington, MA 02420 (US) (74) Representative: Jones Day  Rechtsanwälte, Attorneys-at-Law, Patentanwälte Prinzregentenstrasse 11 80538 München 80538 München (DE)