(19)

(11)

EP 3 365 819 A2

(12)

(88) Date of publication A3: 03.08.2017 (43) Date of publication: 29.08.2018 Bulletin 2018/35 (21) Application number: 16858475.3 (22) Date of filing: 22.10.2016

(51) International Patent Classification (IPC):  G06F 19/16(2011.01) C07D 413/12(2006.01) C07D 405/14(2006.01) C07D 231/56(2006.01) C07D 495/04(2006.01) C07D 279/16(2006.01) A61K 31/538(2006.01) A61K 31/427(2006.01) A61K 31/167(2006.01) A61K 31/513(2006.01) A61K 31/4162(2006.01) C07D 265/36(2006.01) C07D 309/34(2006.01) C07D 417/12(2006.01) C07D 405/12(2006.01) C07D 249/12(2006.01) A61K 31/351(2006.01) A61K 31/4196(2006.01) A61K 31/18(2006.01) A61K 31/416(2006.01) A61K 31/4025(2006.01) (86) International application number: PCT/ZA2016/050042 (87) International publication number: WO 2017/070719 (27.04.2017 Gazette 2017/17)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 22.10.2015 ZA 201507849 (71) Applicant: Mangosuthu University Of Technology 4031 Durban (ZA)	(72) Inventor: GUMEDE, Njabulo Joyfull 4004 Durban (ZA) (74) Representative: Allen, Matthew Emmerson  ALLEN IP Limited 3 Windsor Terrace Hagley Road Birmingham B16 8UH Birmingham B16 8UH (GB)