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EP 3 367 785 A2

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(88) Date of publication A3: 01.06.2017 (43) Date of publication: 05.09.2018 Bulletin 2018/36 (21) Application number: 16860830.5 (22) Date of filing: 27.10.2016

(51) International Patent Classification (IPC):  A01K 67/00(2006.01) C12N 15/85(2006.01) A61D 19/04(2006.01) C12N 5/07(2010.01) A01N 1/02(2006.01) (86) International application number: PCT/US2016/059206 (87) International publication number: WO 2017/075276 (04.05.2017 Gazette 2017/18)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 27.10.2015 US 201562246926 P 27.10.2015 US 201562246927 P 27.10.2015 US 201562246929 P 27.10.2015 US 201562246947 P 27.10.2015 US 201562247092 P 27.10.2015 US 201562247096 P 27.10.2015 US 201562247115 P 27.10.2015 US 201562247117 P 27.10.2015 US 201562247118 P 27.10.2015 US 201562247122 P (71) Applicants: Regents of the University of Minnesota Minneapolis, MN 55455 (US) Recombinetics, Inc. Saint Paul, MN 55104 (US)

(72) Inventors: ASAKURA, Atsushi Minneapolis, MN 55414 (US) ARAVALLI, Raj Eden Prairie, MN 55347 (US) CHEERAN, Maxin Shakopee, MN 55379 (US) DUTTON, James Minneapolis, MN 55455 (US) GARRY, Daniel, J. St. Paul, MN 55125 (US) GARRY, Mary, G. St. Paul, MN 55125 (US) GRAHAM, Melanie Minneapolis, MN 55455 (US) LI, Ling Plymouth, MN 55446 (US) LOW, Walter Minneapolis, MN 55455 (US) PANOSKALTSIS-MORTARI, Angela Woodbury, MN 55125 (US) O'BRIEN, Timothy Cokato, MN 55321 (US) STEER, Clifford Eagan, MN 55122 (US) TOLAR, Jakup Minneapolis, MN 55406 (US) CARLSON, Daniel, F. Woodbury, MN 55125 (US) FAHRENKRUG, Scott, C. Minneapolis, MN 55418 (US) KOYANO-NAKAGAWA, Naoko Shoreview, MN 55126 (US) PARR, Ann Excelsior, MN 55331 (US) (74) Representative: Reitstötter Kinzebach  Patentanwälte Sternwartstrasse 4 81679 München 81679 München (DE)