(19)

(11)

EP 3 370 597 A1

(12)

(43) Date of publication: 12.09.2018 Bulletin 2018/37 (21) Application number: 16862995.4 (22) Date of filing: 03.11.2016

(51) International Patent Classification (IPC):  A61B 3/16(2006.01) A61K 39/395(2006.01) C07K 16/00(2006.01) A61K 51/00(2006.01) A61K 39/00(2006.01) (86) International application number: PCT/US2016/060383 (87) International publication number: WO 2017/079473 (11.05.2017 Gazette 2017/19)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 03.11.2015 US 201562250102 P (71) Applicant: The Brigham and Women's Hospital, Inc. Boston, MA 02115 (US)	(72) Inventors: YU, Paul B. Boston, Massachusetts 02114 (US) DICARLI, Marcelo Needham, Massachusetts 02494 (US) (74) Representative: Kalkoff & Partner  Patentanwälte Martin-Schmeisser-Weg 3a-3b 44227 Dortmund 44227 Dortmund (DE)