(19)

(11)

EP 3 370 765 A1

(12)

(43) Date of publication: 12.09.2018 Bulletin 2018/37 (21) Application number: 16863078.8 (22) Date of filing: 04.11.2016

(51) International Patent Classification (IPC):  A61K 39/12(2006.01) C12N 7/01(2006.01) A61K 39/145(2006.01) (86) International application number: PCT/US2016/060631 (87) International publication number: WO 2017/079625 (11.05.2017 Gazette 2017/19)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 06.11.2015 US 201562285732 P (71) Applicant: University Of South Alabama Mobile, AL 36608 (US)	(72) Inventors: SOLODUSHKO, Victor, G. Mobile, AL 36608 (US) FOUTY, Brian Mobile, AL 36608 (US) BITKO, Vira Mobile, AL 36608 (US) (74) Representative: Cabinet Netter  36, avenue Hoche 75008 Paris 75008 Paris (FR)