(19)

(11)

EP 3 371 203 A1

(12)

(43) Date of publication: 12.09.2018 Bulletin 2018/37 (21) Application number: 16809557.8 (22) Date of filing: 02.11.2016

(51) International Patent Classification (IPC):  C07K 5/078(2006.01) A61K 49/00(2006.01) C07F 9/58(2006.01) C07F 9/38(2006.01) C07K 5/062(2006.01) C07F 9/572(2006.01) C07F 9/6509(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2016/060075 (87) International publication number: WO 2017/079262 (11.05.2017 Gazette 2017/19)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 02.11.2015 US 201562249382 P (71) Applicant: University Of Rochester Rochester, NY 14642 (US)	(72) Inventors: EBETINO, Frank Venice, FL 34285 (US) BOECKMAN, Robert Honeoye Falls, NY 14472 (US) XING, Lianping Webster, NY14580 (US) XIAO, Lifeng Rochester, NY 14620 (US) BOYCE, Brendan Woosbury, NY 11797 (US) (74) Representative: Brand, Thomas Louis  TL Brand & Co 50 Eastcastle Street London W1W 8EA London W1W 8EA (GB)