(19)
(11) EP 3 371 208 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
23.10.2024 Bulletin 2024/43

(45) Mention of the grant of the patent:
18.09.2024 Bulletin 2024/38

(21) Application number: 16794878.5

(22) Date of filing: 01.11.2016
(51) International Patent Classification (IPC): 
C07K 14/705(2006.01)
A61K 38/17(2006.01)
(52) Cooperative Patent Classification (CPC):
C07K 2319/30; A61K 38/00; C07K 14/70532; A61P 35/00; A61P 43/00
(86) International application number:
PCT/US2016/059838
(87) International publication number:
WO 2017/079117 (11.05.2017 Gazette 2017/19)

(54)

CD80 EXTRACELLULAR DOMAIN POLYPEPTIDES AND THEIR USE IN CANCER TREATMENT

POLYPEPTIDE DER EXTRAZELLULÄREN DOMÄNE VON CD80 UND DEREN VERWENDUNG IN DER KREBSBEHANDLUNG

POLYPEPTIDES À DOMAINE EXTRACELLULAIRE CD80 ET LEUR UTILISATION DANS LE TRAITEMENT DU CANCER


(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated Extension States:
BA ME
Designated Validation States:
MA MD

(30) Priority: 02.11.2015 US 201562249836 P
11.08.2016 US 201662373654 P

(43) Date of publication of application:
12.09.2018 Bulletin 2018/37

(60) Divisional application:
24200732.6

(73) Proprietor: Five Prime Therapeutics, Inc.
Thousand Oaks, CA 91320 (US)

(72) Inventors:
  • BRENNAN, Thomas
    South San Francisco, California 94080 (US)
  • BELLOVIN, David
    South San Francisco, California 94080 (US)
  • BUSHA, David
    South San Francisco, California 94080 (US)
  • SENNINO, Barbara
    South San Francisco, California 94080 (US)

(74) Representative: Dörries, Hans Ulrich 
df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16
80333 München
80333 München (DE)


(56) References cited: : 
   
  • BORK K ET AL: "Increasing the sialylation of therapeutic glycoproteins: the potential of the sialic acid biosynthetic pathway", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN CHEMICAL SOCIETY AND AMERICAN PHARMACEUTICAL ASSOCIATION, US, vol. 98, no. 10, 1 October 2009 (2009-10-01), pages 3499 - 3508, XP002572996, ISSN: 0022-3549, [retrieved on 20090206], DOI: 10.1002/JPS.21684
  • S. T. HAILE ET AL: "Soluble CD80 Restores T Cell Activation and Overcomes Tumor Cell Programmed Death Ligand 1-Mediated Immune Suppression", THE JOURNAL OF IMMUNOLOGY, vol. 191, no. 5, 5 August 2013 (2013-08-05), US, pages 2829 - 2836, XP055334763, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1202777
  • S. T. HAILE ET AL: "A Soluble Form of CD80 Enhances Antitumor Immunity by Neutralizing Programmed Death Ligand-1 and Simultaneously Providing Costimulation", CANCER IMMUNOLOGY RESEARCH, vol. 2, no. 7, 2 April 2014 (2014-04-02), US, pages 610 - 615, XP055334764, ISSN: 2326-6066, DOI: 10.1158/2326-6066.CIR-13-0204
  • OSTRAND-ROSENBERG SUZANNE ET AL: "Novel strategies for inhibiting PD-1 pathway-mediated immune suppression while simultaneously delivering activating signals to tumor-reactive T cells", CANCER IMMUNOLOGY, IMMUNOTHERAPY, SPRINGER, BERLIN/HEIDELBERG, vol. 64, no. 10, 20 March 2015 (2015-03-20), pages 1287 - 1293, XP035533178, ISSN: 0340-7004, [retrieved on 20150320], DOI: 10.1007/S00262-015-1677-5
  • DANIEL M. CZAJKOWSKY ET AL: "Fc-fusion proteins: new developments and future perspectives", EMBO MOLECULAR MEDICINE, vol. 4, no. 10, 26 July 2012 (2012-07-26), pages 1015 - 1028, XP055160259, ISSN: 1757-4676, DOI: 10.1002/emmm.201201379
  • RICARDO J. SOLÁ ET AL: "Glycosylation of Therapeutic Proteins", BIODRUGS, vol. 24, no. 1, 1 February 2010 (2010-02-01), pages 9 - 21, XP055016446, ISSN: 1173-8804, DOI: 10.2165/11530550-000000000-00000
   
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