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EP 3 373 923 A1

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(43) Date of publication: 19.09.2018 Bulletin 2018/38 (21) Application number: 16865158.6 (22) Date of filing: 11.11.2016

(51) International Patent Classification (IPC):  A61K 31/198(2006.01) A61K 31/195(2006.01) A61K 9/00(2006.01) A61P 1/16(2006.01) A61K 31/192(2006.01) C07C 57/32(2006.01) A61P 3/00(2006.01) (86) International application number: PCT/US2016/061678 (87) International publication number: WO 2017/083758 (18.05.2017 Gazette 2017/20)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 13.11.2015 US 201562255300 P 08.01.2016 US 201662276754 P 19.04.2016 US 201615133087 (71) Applicant: Ocera Therapeutics, Inc. Hazelwood, MO 63042 (US)	(72) Inventors: WANG, Laurene Chapel Hill, NC 27516 (US) GRAIS, Linda S. Hazelwood, MO 63042 (US) BUKOFZER, Stan Hazelwood, MO 63042 (US) (74) Representative: J A Kemp  14 South Square Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)