(19)

(11)

EP 3 374 371 A1

(12)

(43) Date of publication: 19.09.2018 Bulletin 2018/38 (21) Application number: 16864870.7 (22) Date of filing: 08.11.2016

(51) International Patent Classification (IPC):  C07K 1/14(2006.01) A61K 39/395(2006.01) C07K 16/28(2006.01) C07D 209/16(2006.01) (86) International application number: PCT/US2016/061011 (87) International publication number: WO 2017/083314 (18.05.2017 Gazette 2017/20)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 09.11.2015 US 201562252628 P (71) Applicant: University of Notre Dame Notre Dame, IN 46556 (US)	(72) Inventors: BILGICER, Basar Notre Dame, IN 46556 (US) MUSTAFAOGLU, Nur Notre Dame, IN (US) KIZILTEPE BILGICER, Tanyel Notre Dame, IN 46556 (US) (74) Representative: Appleyard Lees IP LLP  15 Clare Road Halifax HX1 2HY Halifax HX1 2HY (GB)