(19)

(11)

EP 3 380 082 A2

(12)

(88) Date of publication A3: 03.08.2017 (43) Date of publication: 03.10.2018 Bulletin 2018/40 (21) Application number: 16816494.5 (22) Date of filing: 23.11.2016

(51) International Patent Classification (IPC):  A61K 9/127(2006.01) A61K 31/70(2006.01) A61K 31/704(2006.01) A61K 31/505(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2016/063668 (87) International publication number: WO 2017/091767 (01.06.2017 Gazette 2017/22)

(84) Designated Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR Designated Extension States: BA ME Designated Validation States: MA MD (30) Priority: 25.11.2015 US 201562259757 P 14.09.2016 US 201662394567 P (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, CA 94607-5200 (US)	(72) Inventors: MITRAGOTRI, Samir Santa Barbara, CA 93111 (US) BROTO, Marta Santa Barbara, CA 93106-2055 (US) CAMACHO, Kathryn, M. Santa Barbara, CA 93103 (US) MENEGATTI, Stefano Raleigh, NC 27606 (US) (74) Representative: Hutter, Anton et al Venner Shipley LLP 200 Aldersgate London EC1A 4HD London EC1A 4HD (GB)