(19)
(11) EP 3 380 471 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
19.01.2022 Bulletin 2022/03

(45) Mention of the grant of the patent:
08.09.2021 Bulletin 2021/36

(21) Application number: 16869342.2

(22) Date of filing: 25.11.2016
(51) International Patent Classification (IPC): 
C07D 471/04(2006.01)
A61P 25/00(2006.01)
 A61K 31/4985(2006.01)
(52) Cooperative Patent Classification (CPC):
C07D 471/04; A61P 25/00; A61K 31/4985; A61K 31/197; A61K 31/165
(86) International application number:
PCT/US2016/063779
(87) International publication number:
WO 2017/091818 (01.06.2017 Gazette 2017/22)

(54)

TETRAHYDRO-8H-PYRIDO[1,2-A]PYRAZINE-8-ONES AS COMT INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS

TETRAHYDRO-8H-PYRIDO[1,2-A]PYRAZINE-8-ON ABKÖMMLINGE ALS COMT-HEMMENDE VERBINDUNGEN ZUR BEHANDLUNG NEURODGENERATIVER ERKRANKUNGEN

DÉRIVÉS DE TETRAHYDRO-8H-PYRIDO[1,2-A]PYRAZINE-8-ONES EN TANT QU`INHIBITEURS DE COMT POUR LE TRAITEMENT DES MALADIES NEURODEGENERATIVES

(84) Designated Contracting States:
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

(30) Priority: 25.11.2015 US 201562260067 P

(43) Date of publication of application:
03.10.2018 Bulletin 2018/40

(73) Proprietor: Lieber Institute Inc. DBA Lieber Institute For Brain Development
Baltimore, Maryland 21205 (US)

(72) Inventors:
  • BARROW, James
    Arnold, Maryland 21012 (US)
  • ERNST, Glen
    Bear, Delaware 19701 (US)
  • SWINNEN, Dominique
    1420 Braine l'Alleud (BE)
  • MONTEL, Florian
    88487 Meitingen (DE)
  • DEFAYS, Sabine
    1480 Tubize (BE)
  • HUANG, Yifang
    Lansdale, PA 19446 (US)
  • DE LÉON, Pablo
    Baltimore, MD 21230 (US)
  • POSLUSNEY, Michael Steven
    Owings Mills, MD 21117 (US)

(74) Representative: Hoffmann Eitle 
Patent- und Rechtsanwälte PartmbB Arabellastraße 30
81925 München
81925 München (DE)


(56) References cited: : 
WO-A1-2005/016344
US-A1- 2011 117 192
 WO-A1-2011/109254
US-A1- 2013 197 219
   
  • SCOTT T. HARRISON ET AL: "Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT)", ACS MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 3, 26 January 2015 (2015-01-26), pages 318-323, XP055575950, ISSN: 1948-5875, DOI: 10.1021/ml500502d
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).